[Association of adiponectin gene polymorphrism with metabolic syndrome in older Han adults from major cities in China].

OBJECTIVE

To investigate the association of adiponectin gene rs2241766 (T45G) and rs15011299 (G276T) single nucleotide polymorphrism (SNP) with metabolic syndrome (MS) in older han adults from major cities in China.

METHODS

A total of 907 older Han adults were selected from 18 major cities of the China National Nutrition and Health Survey in 2002. According to the MS definition proposed by International Diabetes Federation, the subjects were divided into MS and control groups. Plasma adiponectin and Genomic DNA was isolated from blood and insulin concentrations were measured. genotypes of rs2241766 and rs15011299 were identified by Taqman method. Association There was of genotypes of adiponectin gene SNPs with MS was analyzed.

RESULTS

significant difference in the distribution of genotypes of rs15011299 SNP between the MS and control group. The T allele frequency of rs15011299 was significantly increased in MS group. For rs15011299 site, there were significant differences of BMI and adiponectin level among the subjects carried GG, GT or TT genotypes. The GG+GT carriers had lower BMI, waist circumference, insulin level and higher adiponectin level than those of TT carriers. For rs2241766 site, there were significant differences of BMI and diastolic blood pressure (DBP) among the subjects carried TT, TG or GG genotypes. The TT carriers had higher BMI, waist circumference and DBP than those of GG+GT carriers. The TT carriers in rsl5011299 had higher risk for MS than GG carriers (OR for TT v. s. GG=3.19; 95% CI 1.31-7.78). No association was found in rs2241766 with MS.

CONCLUSION

The adiponectin gene rs15011299 polymorphrism may be associated with pathogenesis of MS in older Han adults. G-->T variance may be associated with an increased risk of MS and result in a decreased level of aiponectin and increments of waist circumference and BMI.