National Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Biomed Environ Sci. 2010 Feb;23(1):53-61. doi: 10.1016/S0895-3988(10)60032-3.
To investigate the association between adiponectin and metabolic syndrome (MetS) and related diseases in older adults from major cities of China.
A total of 2 049 adults at the age of 60-96 years from 18 major cities of China were enrolled in the study. Plasma adiponectin and insulin concentrations were measured. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). The definitions proposed by International Diabetes Federation (IDF) and American Heart Association/National Heart, Lung, and Blood Institute (AHA/NLHBI) were used to identify MetS.
The adiponectin concentration increased with the advance of age and was higher in women than in men. The sex specific adiponectin concentration was inversely correlated with body mass index (BMI), waist circumference, diastolic blood pressure, triglycerides, glucose and fasting blood insulin, and positively correlated with HDL-C (P < 0.001). The adiponectin concentration decreased with increasing MetS components. Compared with the 4th sex-specific adiponectin quartile, the odds ratio (OR) for prevalent MetS-IDF and MetS-AHA/NLHBI in subjects of the 1st quartile group was 3.25 (95% CI: 2.24, 4.71) and 3.21 (95% CI: 2.26, 4.55), respectively. The association was independent of age, sex, life-style factors, medication, family history of chronic diseases, BMI, and HOMA-IR. The OR for MetS was much higher than those of MetS components and its related diseases.
Adiponectin is strongly associated with MetS independent of insulin resistance and obesity in older adults from major cities in China. The adiponectin concentration is a useful predictor for the risk of MetS.
探讨中国大城市老年人脂联素与代谢综合征（MetS）及相关疾病的关系。
本研究共纳入中国 18 个主要城市 2049 名年龄在 60-96 岁的成年人。检测血浆脂联素和胰岛素浓度，用稳态模型评估胰岛素抵抗（HOMA-IR）评估胰岛素抵抗。采用国际糖尿病联盟（IDF）和美国心脏协会/美国国立心肺血液研究所（AHA/NHLBI）提出的定义来识别 MetS。
脂联素浓度随年龄增长而升高，女性高于男性。脂联素浓度与性别特异性呈负相关，与体重指数（BMI）、腰围、舒张压、甘油三酯、血糖和空腹胰岛素呈负相关，与高密度脂蛋白胆固醇（HDL-C）呈正相关（P<0.001）。脂联素浓度随 MetS 成分的增加而降低。与第 4 个性别特异性脂联素四分位数相比，第 1 个四分位数组中 MetS-IDF 和 MetS-AHA/NHLBI 的患病率比值比（OR）分别为 3.25（95%CI：2.24，4.71）和 3.21（95%CI：2.26，4.55）。这种关联独立于年龄、性别、生活方式因素、药物、慢性病家族史、BMI 和 HOMA-IR。MetS 的 OR 明显高于 MetS 各组分及其相关疾病的 OR。
脂联素与中国大城市老年人的 MetS 独立于胰岛素抵抗和肥胖密切相关。脂联素浓度是 MetS 风险的一个有用预测指标。
