[Effects of activate-depress-free-repeat (ADFR) treatment on bone mass in old beagles with osteoporosis].

The effect of active-depress-free-repeat (ADFR) treatment on bone mass in the distal tibia was studied in female old beagles during a 24-month period by single photon absorptiometry. Bone quality of the iliac bone and rib was periodically analyzed histomorphometrically. In ADFR-treated dogs, bone mass decreased (6.7%) at 6.8 months of the treatment, followed by a 4.4% increase at about 19 months. The control animals showed a 4.3% decrease of bone mass during a 24-month period. A histomorphometric study revealed an increase of mean wall thickness, and mineral appositional rate in the iliac bone and rib at 12 and 21 months of treatment during the course of ADFR treatment. The present experimental study has clearly demonstrated that ADFR treatment was effective to increase the reduced bone mass in old female beagles with osteoporosis.