诱导痰与支气管肺泡灌洗在年轻不排痰囊性纤维化患儿中的比较。
Induced sputum compared to bronchoalveolar lavage in young, non-expectorating cystic fibrosis children.
机构信息
Graub CF Center and Pulmonary Institute, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petah Tikva 49202, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.
Cystic Fibrosis Unit, Paediatric Department, Mid-Western Regional Hospital, Dooradoyle, Limerick, Ireland.
出版信息
J Cyst Fibros. 2014 Jan;13(1):106-10. doi: 10.1016/j.jcf.2013.05.013. Epub 2013 Jun 24.
BACKGROUND
Induced sputum (IS) is feasible and safe in young CF children and is a readily accessible, non-invasive technique. However, it has not been compared to bronchoalveolar lavage (BAL), the gold standard for diagnosing lower airway infection.
METHODS
We compared bacterial yield from IS and BAL in 11 non-expectorating CF children, aged 3 to 7.4 years. IS samples were obtained in 10/11 cases.
RESULTS
Eight out of ten had the same predominant bacteria cultured from IS and BAL: Pseudomonas aeruginosa and Stenotrophomonas maltophilia[1], Staphylococcus aureus[3], and upper respiratory tract flora [4]. In one, Serratia marcescens and Haemophilus parainfluenzae were cultured from IS alone, whereas in one, non-group B Haemophilus influenzae was cultured from BAL alone.
CONCLUSIONS
As proof of principle, IS samples showed good bacteriologic correlation with BAL. Larger studies are recommended to confirm IS as a clinically valuable tool and measure for early intervention studies in young CF children.
背景
诱导痰（IS）在年轻 CF 儿童中是可行且安全的，并且是一种易于获得的非侵入性技术。然而，它尚未与支气管肺泡灌洗（BAL）进行比较，后者是诊断下呼吸道感染的金标准。
方法
我们比较了 11 名非排痰 CF 儿童（年龄 3 至 7.4 岁）的 IS 和 BAL 的细菌产量。在 11 例中，有 10 例获得了 IS 样本。
结果
10 例中有 8 例从 IS 和 BAL 中培养出相同的主要细菌：铜绿假单胞菌和嗜麦芽寡养单胞菌[1]、金黄色葡萄球菌[3]和上呼吸道菌群[4]。在 1 例中，IS 仅培养出粘质沙雷氏菌和副流感嗜血杆菌，而在 1 例中，BAL 仅培养出非 B 组流感嗜血杆菌。
结论
作为原理的证明，IS 样本与 BAL 具有良好的细菌学相关性。建议进行更大规模的研究，以确认 IS 作为一种有临床价值的工具和早期干预研究的测量方法，适用于年轻 CF 儿童。
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