Bar-On Ophir, Mei-Zahav Meir, Levine Hagit, Mussaffi Huda, Blau Hannah, Ben Zvi Haim, Prais Dario, Stafler Patrick
Graub CF Center, Pulmonary Institute, Schneider Children's Medical Center of Israel, Petach Tikva 4920235, Israel.
School of Medicine, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv 6997801, Israel.
J Clin Med. 2025 Apr 3;14(7):2437. doi: 10.3390/jcm14072437.
: The prevalence of is increasing in people with Cystic Fibrosis (pwCF), yet its clinical pathogenicity remains controversial. The objective of this study was to chart the longitudinal prevalence and examine clinical associations before and after infection. : This observational, retrospective study was conducted at a single CF center over a 14-year period. Data were collated from patient charts and clinic databases. Patients with sputum cultures were compared to those without the bacterium and analyzed according to whether they had single, intermittent, or chronic infections. : During the study period, an annual average of 124 pwCF were followed up at our clinic, with a median age of 13.6 years (IQR = 7.6-27.7). The detection rate increased from 0 to 6.1%. Twenty-three percent (29/124) of patients had at least one positive culture. The median age at acquisition was 17 years (IQR = 14.5-33). At the time of acquisition, the median FEV was 81% (IQR = 46-94), compared to 90% (IQR = 72-99) for patients without , < 0.001. Patients with tended to demonstrate more chronic (55% vs. 27%, = 0.06) and pancreatic insufficiency (66% vs. 47%, = 0.07). At two years post-acquisition, the median FEV for patients with intermittent and chronically infected decreased by 11.5% (IQR = -3.75-7.5), compared to 1.5% (IQR = -2.5-12.5) for those with a single positive culture, = 0.03. Similarly, pulmonary exacerbations per year became more frequent post-acquisition in intermittent and chronically infected patients: Median (range) 2.5 (0-8) pre-, versus 3.0 (0-9) post-acquisition, = 0.036. : Chronic and intermittent infection with were associated with accelerated lung function decline and increased exacerbation frequency. Larger prospective studies are needed to confirm these findings and examine the effect of eradication on the clinical course.
在囊性纤维化患者（pwCF）中，[细菌名称]的感染率正在上升，但其临床致病性仍存在争议。本研究的目的是记录其纵向感染率，并检查感染前后的临床关联。：这项观察性回顾性研究在一个单一的囊性纤维化中心进行，为期14年。数据来自患者病历和临床数据库。将有[细菌名称]痰培养结果的患者与没有该细菌的患者进行比较，并根据他们是单次、间歇性还是慢性感染进行分析。：在研究期间，我们诊所每年平均随访124名pwCF患者，中位年龄为13.6岁（四分位间距IQR = 7.6 - 27.7）。[细菌名称]的检出率从0上升到6.1%。23%（29/124）的患者至少有一次阳性培养结果。感染时的中位年龄为17岁（IQR = 14.5 - 33）。感染时，中位第一秒用力呼气容积（FEV）为81%（IQR = 46 - 94），而未感染[细菌名称]的患者为90%（IQR = 72 - 99），P < 0.001。感染[细菌名称]的患者往往表现出更多的慢性[疾病名称]（55%对27%，P = 0.06）和胰腺功能不全（66%对47%，P = 0.07）。感染后两年，间歇性和慢性感染患者的中位FEV下降了11.5%（IQR = -3.75 - 7.5），而单次阳性培养结果的患者下降了1.5%（IQR = -2.5 - 12.5），P = 0.03。同样，间歇性和慢性感染患者在感染后每年肺部加重变得更加频繁：感染前中位（范围）为2.5（0 - 8）次，感染后为3.0（0 - 9）次，P = 0.036。：[细菌名称]的慢性和间歇性感染与肺功能加速下降和加重频率增加有关。需要更大规模的前瞻性研究来证实这些发现，并研究根除该细菌对临床病程的影响。
