在特发性肺纤维化中检测 HBoV DNA，德国科隆。
Detection of HBoV DNA in idiopathic lung fibrosis, Cologne, Germany.
机构信息
Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten/Herdecke, Lungenklinik, Ostmerheimer Strasse 200, 51109 Köln, Cologne, Germany.
出版信息
J Clin Virol. 2013 Sep;58(1):325-7. doi: 10.1016/j.jcv.2013.05.020. Epub 2013 Jun 24.
Abstract
We report two confirmed cases of usual interstitial pneumonia (UIP) associated with infection of the human bocavirus (HBoV). In one case HBoV was identified in the bronchoalveolar lavage (BAL) during an acute exacerbation as well as post mortem in different tissues giving raise to the hypothesis that HBoV infections trigger UIP or could be a causative agent and be a systemic component in UIP. In the other case, the UIP was confirmed by radiological methods and HBoV was detected in the BAL during an acute exacerbation. Both cases give raise to the hypothesis that HBoV could be a causative agent of UIP or could contribute to its development and/or acute exacerbations.
摘要
我们报告了两例与人类博卡病毒（HBoV）感染相关的寻常间质性肺炎（UIP）确诊病例。在一例病例中，HBoV 在急性加重期以及不同组织的死后均在支气管肺泡灌洗液（BAL）中被检出，这使得 HBoV 感染引发 UIP 的假说成立，或者 HBoV 可能是一个致病因子，也是 UIP 的一个全身性组成部分。在另一个病例中，UIP 通过影像学方法得到证实，并且在急性加重期时在 BAL 中检测到 HBoV。这两个病例都使得 HBoV 可能是 UIP 的致病因子，或者可能有助于其发展和/或急性加重的假说成立。
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