EA4576 MRGM, University of Bordeaux, Bordeaux, France.
Int J Biochem Cell Biol. 2013 Sep;45(9):2109-18. doi: 10.1016/j.biocel.2013.06.013. Epub 2013 Jun 24.
Mitochondria are crucial organelles that produce and deliver adenosine triphosphate (ATP), by which all cellular processes are driven. Although the mechanisms that control mitochondrial biogenesis, function and dynamics are complex process and vary among different cell types, recent studies provided many new discoveries in this field. Podocyte injury is a crucial step in the development of a large number of glomerular diseases. Glomerular podocytes are unique cells with complex foot processes that cover the outer layer of the glomerular basement membrane, and are the principle cells composing filtration barriers of glomerular capillaries. Little is known on the modalities and the regulation of podocyte's energetics as well as the type of energy substrate primarily used for their activity, recent studies revealed that dysfunction of energy transduction in podocytes may underlie the podocyte injury associated with numerous glomerular diseases. We herein review and discuss the importance of a fine regulation of energy metabolism in podocytes for maintaining their cellular structure and related kidney function. In the future, understanding these mechanisms will open up new areas of treatment for glomerular diseases.
线粒体是产生和传递三磷酸腺苷（ATP）的关键细胞器，所有细胞过程都由其驱动。尽管控制线粒体生物发生、功能和动力学的机制是一个复杂的过程，并且在不同的细胞类型中有所不同，但最近的研究在这一领域提供了许多新的发现。足细胞损伤是许多肾小球疾病发展过程中的关键步骤。肾小球足细胞是具有复杂足突的独特细胞，覆盖肾小球基底膜的外层，是构成肾小球毛细血管滤过屏障的主要细胞。目前对于足细胞的能量代谢方式和调节以及其活动主要使用的能量底物类型知之甚少，最近的研究表明，足细胞能量转导功能障碍可能是与许多肾小球疾病相关的足细胞损伤的基础。本文综述并讨论了精细调节足细胞能量代谢对于维持其细胞结构和相关肾功能的重要性。未来，了解这些机制将为肾小球疾病的治疗开辟新的领域。
