血清中胃蛋白酶原浓度与胃腺瘤及腺癌病理组织学参数之间的关系

[The relationship between concentrations of pepsinogens in blood serum and pathohystologic parameters of stomach adenomas and adenocarcinomas].

作者信息

Sosnina A V, Sorokina N N, Autenshlius A I, Morozov D V, Isakova N B, Vankhal'skiĭ A V, Fursov S A

出版信息

Klin Lab Diagn. 2013 Feb(2):21-3.

Abstract

The article demonstrates that in patients with adenomas of stomach the concentration of pepsinogen I in blood serum and the rate between pepsinogen I and pepsinogen II is decreased. In case of adenomas and adenocarcinomas of stomach the concentration of pepsinogen I and the rate between pepsinogen I and pepsinogen II are in inverse correlation relationship with indicators of proliferative activity of epithelial cells and tumor cells correspondingly. The threshold level was the rate between pepsinogen I and pepsinogen II can be used as criteria of intensity ofproliferative activity of epithelial cells of adenomas and cells of adenocarcinomas of stomach.

摘要

文章表明，在胃腺瘤患者中，血清中胃蛋白酶原I的浓度以及胃蛋白酶原I与胃蛋白酶原II的比率降低。在胃腺瘤和腺癌病例中，胃蛋白酶原I的浓度以及胃蛋白酶原I与胃蛋白酶原II的比率分别与上皮细胞和肿瘤细胞的增殖活性指标呈负相关关系。胃蛋白酶原I与胃蛋白酶原II的比率的阈值水平可作为胃腺瘤上皮细胞和胃腺癌细胞增殖活性强度的标准。