Department of Digestive Diseases, Wuxi Huishan District People's Hospital, Wuxi, Jiangsu, China.
Department of Digestive Diseases, Qinghai Provincial People's Hospital, Xining, Qinghai, China.
J Int Med Res. 2020 Mar;48(3):300060520914826. doi: 10.1177/0300060520914826.
Diagnosing gastric cancer (GC) at early stages is important for reducing its mortality. This study evaluated the diagnostic value of serum pepsinogen (PG) I, PGII, and gastrin-17 (G17) levels in screening for early-stage GC.
Serum levels of PGI, PGII, and G17 were measured in patients with upper digestive tract symptoms or GC family histories, and the PGI to PGII ratio (PGR) was calculated. Receiver operator characteristic curves were used to determine the thresholds of PGI, PGR, and G17 for GC diagnosis.
Among the 949 patients examined by gastroscopy, 13 (1.37%) had GC, including five cases of early-stage GC and eight cases of progressive GC. PGI, PGR, and G17 showed good specificity and sensitivity for early-stage and progressive GC. The optimal thresholds of PGI, G17, and PGR were 71.85 μg/L, 15.65 pmol/L and 5.04 for the diagnosis of early-stage GC, respectively, and were 42.55 μg/L, 20.55 pmol/L, and 2.79 for the diagnosis of progressive GC, respectively.
Combining PG and G17 serum levels with gastroscopy could be a promising approach to screen for early-stage GC.
早期诊断胃癌（GC）对于降低其死亡率至关重要。本研究评估了血清胃蛋白酶原（PG）I、PGII 和胃泌素-17（G17）水平在早期 GC 筛查中的诊断价值。
对有上消化道症状或 GC 家族史的患者进行血清 PG I、PGII 和 G17 水平检测，并计算 PG 比值（PGR）。采用受试者工作特征曲线确定 PG I、PGR 和 G17 用于 GC 诊断的阈值。
在接受胃镜检查的 949 例患者中，有 13 例（1.37%）患有 GC，其中包括 5 例早期 GC 和 8 例进展期 GC。PGI、PGR 和 G17 对早期和进展期 GC 具有良好的特异性和敏感性。早期 GC 诊断的最佳 PG I、G17 和 PGR 阈值分别为 71.85 μg/L、15.65 pmol/L 和 5.04，进展期 GC 诊断的最佳 PG I、G17 和 PGR 阈值分别为 42.55 μg/L、20.55 pmol/L 和 2.79。
将 PG 和 G17 血清水平与胃镜检查相结合可能是一种很有前途的早期 GC 筛查方法。
