Baĭrakova Iu V, Kazachek Ia V, Gruzdeva O V, Sergeeva T Iu, Grigor'ev A M, Ivanov S V
Klin Lab Diagn. 2013 Mar(3):3-6.
The article presents the assessment of prognostic value of perioperative level of C-reactive protein in the development of post-operative cardio-vascular complications in patients with ischemic heart disease and underwent coronary artery bypass grafting. The sample consisted of 99 patients with stable forms of ischemic heart disease and underwent the planned coronary artery bypass grafting. The average age of patients was 58 +/- 4.19 years. All patients were applied direct revascularization of myocardium in conditions of artificial blood circulation. The patients were divided on the groups depending on occurrence of post-operational cardio-vascular complications. The group I consisted of 42 patients with non-complicated post-operational period (42%). The group 2 consisted of 57 patients with cardio-vascular complications and included the subgroup of 24 patients with fibrillation of atriums developed in post-operational period. The concentration of C-reactive protein was analyzed in blood serum one day before the operation and at first and seventh days after operation. The post-operative period after application of coronary artery bypass in conditions of ischemic heart disease is characterized by activation of inflammation reaction evaluated by concentration of C-reactive protein. The pre-operation level of C-reactive protein can be used as prognostic marker of development of cardio-vascular complications, post-operative fibrillation of atriums after application of coronary artery bypass in particular
本文介绍了对缺血性心脏病患者行冠状动脉搭桥术后围手术期C反应蛋白水平对术后心血管并发症发生的预后价值评估。样本包括99例稳定型缺血性心脏病患者，均接受了计划性冠状动脉搭桥术。患者的平均年龄为58±4.19岁。所有患者均在人工血液循环条件下进行心肌直接血运重建。根据术后心血管并发症的发生情况将患者分为不同组。第一组由42例术后无并发症的患者组成（42%）。第二组由57例有心血管并发症的患者组成，其中包括24例术后发生心房颤动的亚组。在手术前一天以及术后第一天和第七天分析血清中C反应蛋白的浓度。在缺血性心脏病患者行冠状动脉搭桥术后，围手术期以C反应蛋白浓度评估的炎症反应激活为特征。术前C反应蛋白水平可作为心血管并发症发生的预后标志物，尤其是冠状动脉搭桥术后的术后心房颤动。
