Vohr B R, Karp D, O'Dea C, Darrow D, Coll C G, Lester B M, Brown L, Oh W, Cashore W
Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Brown University Program in Medicine, Providence 02905.
J Pediatr. 1990 Aug;117(2 Pt 1):288-91. doi: 10.1016/s0022-3476(05)80549-9.
The purpose of this study was to test the hypotheses that newborn infants with moderate serum bilirubin concentrations have depressed Brazelton scores and increased brain-stem conduction time and that serum bilirubin levels correlate with Brazelton behavior scores and brain-stem auditory evoked response changes. Fifty term infants who were enrolled into either a low serum bilirubin group (less than 8 mg/dl) or a moderate serum bilirubin group (10 to 20 mg/dl) were tested with the Brazelton Neonatal Behavioral Assessment Scale and a brain-stem auditory evoked response test. Partial correlation analysis controlling for phototherapy revealed that increased bilirubin concentration correlated negatively with the Brazelton orientation and with state range clusters and individual Brazelton test items that involve auditory processing. Increased bilirubin concentration correlated with an increased latency of brain-stem auditory evoked response wave 4, 5. An increased interpeak 1-5 (brain-stem conduction time) correlated with the decreased animate visual and auditory item. We conclude that moderate hyperbilirubinemia in term infants affects both infant behavior, as measured by specific components of the Brazelton test, and brain-stem conduction time, as measured by the brain-stem auditory evoked response test.
血清胆红素浓度中等的新生儿布雷泽尔顿评分降低、脑干传导时间延长，且血清胆红素水平与布雷泽尔顿行为评分及脑干听觉诱发电位变化相关。五十名足月婴儿被纳入低血清胆红素组（低于8mg/dl）或中等血清胆红素组（10至20mg/dl），并接受了布雷泽尔顿新生儿行为评估量表测试及脑干听觉诱发电位测试。在控制光疗的偏相关分析中发现，胆红素浓度升高与布雷泽尔顿定向、状态范围集群以及涉及听觉处理的个别布雷泽尔顿测试项目呈负相关。胆红素浓度升高与脑干听觉诱发电位第4、5波潜伏期延长相关。峰间期1-5（脑干传导时间）延长与有生命视觉和听觉项目减少相关。我们得出结论，足月婴儿的中度高胆红素血症会影响通过布雷泽尔顿测试特定组成部分测量的婴儿行为，以及通过脑干听觉诱发电位测试测量的脑干传导时间。
