Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0377, USA.
Immunity. 2013 Jun 27;38(6):1081-3. doi: 10.1016/j.immuni.2013.06.002.
How lymphoid cell fate is orchestrated in early hematopoietic progenitors remains poorly understood. In this issue of Immunity, Satoh et al. (2013) show that the chromatin remodeler Satb1 promotes lymphocyte differentiation in both young and aged stem cells.
早期造血祖细胞中淋巴细胞命运是如何协调的,目前仍知之甚少。在本期《免疫》杂志中,Satoh 等人(2013)表明,染色质重塑因子 Satb1 可促进年轻和衰老干细胞中的淋巴细胞分化。