Department of Pathology, TU Munich, Ismaningerstraße 22, 81675 München, Germany.
Best Pract Res Clin Gastroenterol. 2013 Apr;27(2):285-97. doi: 10.1016/j.bpg.2013.04.002.
The neoplasms of the biliary tree include the carcinomas of the intra- and extrahepatic bile ducts, the gallbladder and the ampulla. Two types of precancerous lesions precede these adenocarcinomas: the flat and non-tumour forming type that is called biliary intraepithelial neoplasia, and the papillary and tumour-forming type that has been named intraductal papillary neoplasm of the bile duct. Rarely also biliary mucinous cystic neoplasm can give rise to invasive biliary adenocarcinomas. This review discusses the pathological, molecular, epidemiological, clinical and prognostic features of the precancerous biliary lesions, separated according to their origin in the bile ducts, the ampulla and the gall bladder.
胆道肿瘤包括肝内外胆管癌、胆囊癌和壶腹癌。两种癌前病变先于这些腺癌发生：一种是扁平且非肿瘤形成的类型，称为胆管上皮内瘤变，另一种是乳头状且肿瘤形成的类型，称为胆管内乳头状肿瘤。胆道黏液囊性肿瘤也很少引起侵袭性胆道腺癌。这篇综述讨论了癌前胆道病变的病理、分子、流行病学、临床和预后特征，根据其在胆管、壶腹和胆囊的起源进行了分类。
