Mayo Clinic Center for Regenerative Medicine, Mayo Clinic, Rochester, MN; Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN; Department of Medical Genetics, Mayo Clinic, Rochester, MN.
Mayo Clin Proc. 2013 Jul;88(7):766-75. doi: 10.1016/j.mayocp.2013.04.017.
The pandemic of chronic diseases, compounded by the scarcity of usable donor organs, mandates radical innovation to address the growing unmet needs of individuals and populations. Beyond life-extending measures that are often the last available option, regenerative strategies offer transformative solutions in treating degenerative conditions. By leveraging newfound knowledge of the intimate processes fundamental to organogenesis and healing, the emerging regenerative armamentarium aims to boost the aptitude of human tissues for self-renewal. Regenerative technologies strive to promote, augment, and reestablish native repair processes, restituting organ structure and function. Multimodal regenerative approaches incorporate transplant of healthy tissues into damaged environments, prompt the body to enact a regenerative response in damaged tissues, and use tissue engineering to manufacture new tissue. Stem cells and their products have a unique aptitude to form specialized tissues and promote repair signaling, providing active ingredients of regenerative regimens. Concomitantly, advances in materials science and biotechnology have unlocked additional prospects for growing tissue grafts and engineering organs. Translation of regenerative principles into practice is feasible and safe in the clinical setting. Regenerative medicine and surgery are, thus, poised to transit from proof-of-principle studies toward clinical validation and, ultimately, standardization, paving the way for next-generation individualized management algorithms.
慢性疾病的大流行，加上可用供体器官的稀缺，要求进行彻底的创新，以满足个人和人群日益增长的未满足需求。除了作为最后选择的延长生命的措施之外，再生策略为治疗退行性疾病提供了变革性的解决方案。通过利用对器官发生和愈合基本过程的新发现知识，新兴的再生武器库旨在提高人体组织的自我更新能力。再生技术旨在促进、增强和重建天然修复过程，恢复器官结构和功能。多模式再生方法将健康组织移植到受损环境中，促使身体在受损组织中产生再生反应，并使用组织工程制造新组织。干细胞及其产物具有形成专门组织和促进修复信号的独特能力，为再生方案提供活性成分。同时，材料科学和生物技术的进步为组织移植物的生长和器官工程开辟了更多的可能性。再生原则在临床环境中的转化是可行和安全的。因此，再生医学和外科手术正从原理验证研究向临床验证，最终向标准化过渡，为下一代个体化管理算法铺平道路。
