Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Curr Opin Chem Biol. 2013 Aug;17(4):546-54. doi: 10.1016/j.cbpa.2013.05.033. Epub 2013 Jun 25.
Cyclotides are bioactive macrocyclic peptides from plants that are characterized by their exceptional stability and potential applications as protein engineering or drug design frameworks. Their stability arises from their unique cyclic cystine knot structure, which combines a head-to-tail cyclic peptide backbone with three conserved disulfide bonds having a knotted topology. Cyclotides are ribosomally synthesized by plants and expressed in a wide range of tissues, including leaves, flowers, stems and roots. Here we describe recent studies that have examined the biosynthesis of cyclotides and in particular the mechanism associated with post-translational backbone cyclization.
环肽是一类源自植物的生物活性大环肽，具有出色的稳定性，有望成为蛋白质工程或药物设计框架的应用。它们的稳定性源于其独特的环半胱氨酸结结构，这种结构将头到尾的环肽主链与具有打结拓扑的三个保守二硫键结合在一起。环肽是由植物通过核糖体合成，并在包括叶子、花朵、茎和根在内的各种组织中表达。本文描述了近期对环肽生物合成的研究，特别是与翻译后骨架环化相关的机制。
