Golding D N
Rheumatology Unit, Princess Alexandra Hospital, Harlow, Essex.
J R Soc Med. 1990 May;83(5):312-4. doi: 10.1177/014107689008300512.
Nine patients had attacks of joint pain and sometimes swelling precipitated by certain foods or associated with allergic manifestations. All were atopic subjects--three having strong evidence of Type I (immediate) allergy and three 'urticarial arthralgia', in which attacks of severe urticaria and joint pain occurred coincidentally. Food allergy appeared to be responsible for the joint symptoms in three patients and in one it was possible to precipitate swelling of a knee due to synovitis with effusion by drinking milk a few hours beforehand, the synovial fluid having mildly inflammatory features and a relatively high eosinophil count. It seems that allergy is an occasional cause of episodic rheumatic pain or synovitis in certain atopic patients, whether or not they have an underlying arthritis. These are usually Type I hypersensitivity reactions, though it is thought that some food-allergic reactions are immune complex-mediated.
9名患者出现关节疼痛发作，有时会因某些食物诱发肿胀或伴有过敏表现。所有患者均为特应性个体——3例有I型（速发型）过敏的确切证据，3例有“荨麻疹性关节痛”，即严重荨麻疹和关节痛发作同时出现。食物过敏似乎是3例患者关节症状的原因，其中1例患者在提前几小时饮用牛奶后可诱发因滑膜炎伴积液导致的膝关节肿胀，滑膜液具有轻度炎症特征且嗜酸性粒细胞计数相对较高。似乎过敏是某些特应性患者发作性风湿性疼痛或滑膜炎的偶尔病因，无论他们是否有潜在关节炎。这些通常是I型超敏反应，不过有人认为一些食物过敏反应是由免疫复合物介导的。
