Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada; Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
J Cyst Fibros. 2014 Jan;13(1):92-8. doi: 10.1016/j.jcf.2013.05.014. Epub 2013 Jul 1.
Exercise is a viable form of therapy for children with cystic fibrosis (CF). Understanding the energy sources used during exercise would aid CF patients in obtaining proper nutrition in order to sustain an active lifestyle.
Six boys with CF (mean age ± SD: 14.8 ± 2.3 yrs, FEV1: 99 ± 18% predicted) and six matched controls (14.0 ± 2.2 yrs) completed a session of two 30 min bouts of cycling at an intensity set at 50% peak mechanical power. Rates of total fat and carbohydrate (CHO) oxidation were calculated from expired gases. Plasma insulin, glucose and free fatty acid (FFA) were determined before, during and at the end of the exercise.
Rates of fat oxidation (expressed in mean mg × kg body weight(-1) × min(-1) ± SD) were significantly lower in children with CF (5.7 ± 1.6) compared to controls (8.6 ± 1.8, p < 0.05). Children with CF also had lower values than controls in amount of fat oxidized (CF: 17.3 ± 5.0 g, controls: 26.1 ± 5.9 g, p < 0.05) and percent of total energy expenditure from fat (CF: 32 ± 6%, controls: 43 ± 7%, p < .0.05), but a higher contribution from CHO (CF: 68 ± 6%, controls: 57 ± 7% p < .0.05). Plasma FFA was significantly lower in children with CF compared to controls during (CF: 252.5 ± 117.9 μM, controls: 602.2 ± 295.6) and at the end of exercise (CF: 430.9 ± 180.6, controls: 1147.5 ± 473.5). There were no differences in the rates of CHO oxidation, insulin or glucose between groups.
Fat metabolism during exercise is impaired in boys with CF and may be attributed to an inability to mobilize FFA.
运动是囊性纤维化（CF）儿童的一种可行治疗形式。了解运动过程中使用的能量来源将有助于 CF 患者获得适当的营养，以维持积极的生活方式。
六名患有 CF（平均年龄 ± 标准差：14.8 ± 2.3 岁，FEV1：99 ± 18%预测值）的男孩和六名匹配的对照者（14.0 ± 2.2 岁）完成了两次 30 分钟的骑行，强度设定为 50%峰值机械功率。从呼出的气体中计算出总脂肪和碳水化合物（CHO）的氧化率。在运动前、运动中和运动结束时测定血浆胰岛素、血糖和游离脂肪酸（FFA）。
CF 患儿（5.7 ± 1.6）的脂肪氧化率（以平均 mg × kg 体重 -1 × min -1 ± 标准差表示）明显低于对照组（8.6 ± 1.8，p < 0.05）。CF 患儿的脂肪氧化量（CF：17.3 ± 5.0 g，对照组：26.1 ± 5.9 g，p < 0.05）和脂肪占总能量消耗的百分比（CF：32 ± 6%，对照组：43 ± 7%，p < 0.05）也低于对照组，但 CHO 的贡献更高（CF：68 ± 6%，对照组：57 ± 7%，p < 0.05）。与对照组相比，CF 患儿在运动中和运动结束时的血浆 FFA 明显较低（CF：252.5 ± 117.9 μM，对照组：602.2 ± 295.6 μM）（CF：430.9 ± 180.6 μM，对照组：1147.5 ± 473.5 μM）。两组之间 CHO 氧化率、胰岛素或血糖无差异。
CF 男孩在运动过程中的脂肪代谢受损，这可能归因于无法动员 FFA。
