通过新型分子内Alder-Rickert反应一锅法合成苯酚衍生物：环己烯酮衍生物3-位芳基取代基对反应活性的影响。
One-pot synthesis of phenol derivatives by the novel intramolecular Alder-Rickert reaction: effects of aryl substituent at the 3-position of cyclohexenone derivatives on reactivity.
作者信息
Kinbara Atsushi, Yamagishi Takehiro, Fujishige Takeshi, Miyaoka Hiroaki
机构信息
School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima 963–8611, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2013;61(7):768-75. doi: 10.1248/cpb.c13-00215.
PMID:23812401
Abstract
We examined In(OTf)3-catalyzed enolization and intramolecular Alder-Rickert reactions of cyclohexenone derivatives. The 3-aryl substituted cyclohexenone derivatives bearing an ethoxycarbonyl-substituted alkyne moiety could be converted into the corresponding phenols in comparatively good yield.
摘要
我们研究了三氟甲磺酸铟（In(OTf)3）催化的环己烯酮衍生物的烯醇化反应和分子内阿尔德-里克特（Alder-Rickert）反应。带有乙氧羰基取代炔基部分的3-芳基取代环己烯酮衍生物能够以相对较好的产率转化为相应的酚类。
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