Di Lorenzo L, Molinini R, Bruno F, De Niccolo M, Assennato G, Lerro A, Ambrosi L
Istituto di Medicina del Lavoro, Università degli Studi di Bari.
Med Lav. 1990 Jan-Feb;81(1):32-8.
The aim of the study was to assess the efficiency of the respiratory system in ensuring the correct dynamics of respiratory gases in subjects chronically exposed to the inhalation of asbestos-cement dust but not yet suffering from parenchymal asbestosis, via measurement of total and partial O2 and CO2 ductance coefficients (Du). Two groups of male workers of working age were selected, the first consisting of 22 workers employed on the manufacture of asbestos-cement products, the second consisting of 26 workers who had never been exposed to the inhalation of significant concentrations of occupational respiratory irritants. The two groups were comparable for age, smoking, and normal spirometric parameters for FVC, FEV1 and PEF, and were free of any type on interstitial lung disease according to ILO standards. In the exposed group, all O2 and CO2 ductance coefficients were significantly lower than in the non-exposed, except DuBCO2 (alveolar-capillary ductance for CO2). Measurement of O2 and CO2 lung ductances at rest thus revealed an impairment of the diffusion and of the interpulmonary exchange of blood and air in subjects chronically exposed to the inhalation of asbestos-cement dust. In the sample under study, such impairment preceded lung damage detectable by spirometric and radiological tests and was an obstacle not only to oxygen intake but also to the elimination of carbon dioxide.
本研究的目的是通过测量总氧和二氧化碳传导系数（Du）以及部分氧和二氧化碳传导系数，评估长期吸入石棉水泥粉尘但尚未患实质性石棉肺的受试者呼吸系统在确保呼吸气体正确动态方面的效率。选择了两组处于工作年龄的男性工人，第一组由22名从事石棉水泥制品制造的工人组成，第二组由26名从未接触过显著浓度职业性呼吸道刺激物的工人组成。两组在年龄、吸烟情况以及FVC、FEV1和PEF的正常肺量计参数方面具有可比性，并且根据国际劳工组织（ILO）标准没有任何类型的间质性肺病。在暴露组中，除了DuBCO2（二氧化碳的肺泡-毛细血管传导率）外，所有氧和二氧化碳传导系数均显著低于未暴露组。因此，对静息状态下氧和二氧化碳肺传导率的测量表明，长期吸入石棉水泥粉尘的受试者存在扩散以及肺内血液与空气交换功能受损的情况。在所研究的样本中，这种损害在通过肺量计和放射学检查可检测到的肺损伤之前就已存在，并且不仅是氧气摄入的障碍，也是二氧化碳排出的障碍。
