Willems J L, Bogaert M G
Naunyn Schmiedebergs Arch Pharmacol. 1975;286(4):429-36. doi: 10.1007/BF00506656.
Imipramine potentiates the dopamine-induced inhibition in the paravertebral lumbar ganglia of the dog. Potentiation by imipramine of the dopamine-induced neurogenic vasodilatation in the isolated perfused gracilis muscle, is seen in cross-circulation preparations only, where imipramine is injected into the perfusion circuit of an isolated perfused gracilis muscle, it antagonizes the dopamine-induced neurogenic vasodilatation. When imipramine is injected intravenously into a dog with an autoperfused gracilis muscle, the peripheral antagonism masks the potentiating effect at the ganglionic level, and the dopamine-induced neurogenic vasodilatation is abolished.
丙咪嗪增强多巴胺对犬腰旁神经节的抑制作用。只有在交叉循环制备中，才可见丙咪嗪对多巴胺诱导的离体灌注股薄肌神经源性血管舒张的增强作用，即当丙咪嗪注入离体灌注股薄肌的灌注回路时，它会拮抗多巴胺诱导的神经源性血管舒张。当将丙咪嗪静脉注射到具有自身灌注股薄肌的犬体内时，外周拮抗作用掩盖了神经节水平的增强作用，多巴胺诱导的神经源性血管舒张被消除。
