2型糖尿病的个性化医疗：未来会怎样？
Personalized medicine in Type 2 diabetes: what does the future hold?
作者信息
Grant Richard W, Wexler Deborah J
机构信息
Massachusetts General Hospital Diabetes Center, Bulfinch 408a, 55 Fruit Street, Boston, MA 02114, USA.
出版信息
Diabetes Manag (Lond). 2012 May;2(3):199-204. doi: 10.2217/dmt.12.15.
The management of patients with Type 2 diabetes is based on a remarkably robust evidence base. Large clinical trials and lengthy observational cohort studies have clearly established the importance of glycemic, blood pressure and lipid level control. Indeed, most elements of guideline-based diabetes care can be supported by clinical research evidence. While such studies are critical for establishing treatment recommendations, the evidence derived from clinical trial participants applies to populations of patients rather than to the individual sitting before the clinician. An important next step in diabetes care would be to develop and implement a framework for personalizing care. In this article, we highlight the major reasons for personalization and discuss what the future of personalized diabetes care may hold.
2型糖尿病患者的管理基于非常坚实的证据基础。大型临床试验和长期观察性队列研究已明确确立了血糖、血压和血脂水平控制的重要性。事实上，基于指南的糖尿病护理的大多数要素都能得到临床研究证据的支持。虽然此类研究对于确立治疗建议至关重要，但从临床试验参与者得出的证据适用于患者群体，而非坐在临床医生面前的个体。糖尿病护理的下一个重要步骤将是制定并实施个性化护理框架。在本文中，我们强调了个性化的主要原因，并讨论了个性化糖尿病护理的未来可能是怎样的。
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