Wu Caiqin, Yang Lin, Hua Cheng, Wang Keqiang, Zhang Tianyu, Dai Peidong
Eye & ENT Hospital, Fudan University, Shanghai, China.
ORL J Otorhinolaryngol Relat Spec. 2013;75(2):108-16. doi: 10.1159/000350569. Epub 2013 Jun 27.
To evaluate geometrical and volume changes of membranous vestibular labyrinths in guinea pigs after endolymphatic hydrops (EH).
The membranous labyrinths of normal guinea pigs and of those with EH for 4 and 8 weeks were reconstructed after being scanned using micro-computed tomography subseqent to being stained in osmium tetroxide (OsO4). The diameters and volumes of the semicircular ducts, ampullae, utricles and saccules were measured based on the three-dimensional models.
The diameters of the ampullae and utricles of EH guinea pigs were greater than those of the normal guinea pigs, while there were no significant differences in the diameters of the semicircular ducts among all groups. The volumes of ampullae, utricles and saccules of the EH groups were greater than those of the control group, but there were no changes in volumes of semicircular ducts after EH.
The dilations of the membranous vestibular labyrinth in guinea pigs with EH mainly occur at the ampullae, utricles and saccules.
评估内淋巴积水（EH）后豚鼠膜性前庭迷路的几何形状和体积变化。
正常豚鼠以及EH造模4周和8周的豚鼠的膜迷路，在经四氧化锇（OsO4）染色后，使用微型计算机断层扫描进行扫描，然后进行重建。基于三维模型测量半规管、壶腹、椭圆囊和球囊的直径和体积。
EH豚鼠的壶腹和椭圆囊直径大于正常豚鼠，而所有组之间半规管直径无显著差异。EH组的壶腹、椭圆囊和球囊体积大于对照组，但EH后半规管体积无变化。
EH豚鼠膜性前庭迷路的扩张主要发生在壶腹、椭圆囊和球囊。
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