Bozkurt Ozan, Bolat Deniz, Demir Omer, Ucer Oktay, Sahin Ali, Ozcift Burak, Pektaş Abdulkadir, Turan Tahir, Gümüş Bilal H, Can Ertan, Bolukbasi Ahmet, Erol Haluk, Esen Adil
Department of Urology, Dokuz Eylul University, Faculty of Medicine, Izmir 35340, Turkey.
Asian J Androl. 2013 Nov;15(6):785-9. doi: 10.1038/aja.2013.44. Epub 2013 Jul 1.
The aim of this study was to evaluate the relationship between lower urinary tract symptoms (LUTSs), erectile dysfunction (ED) and symptomatic late-onset hypogonadism (SLOH) in ageing men in the Aegean region of Turkey. Five hundred consecutive patients >40 years old who had been in a steady sexual relationship for the past 6 months and were admitted to one of six urology clinics were included in the study. Serum prostate-specific antigen and testosterone levels and urinary flow rates were measured. All patients filled out the International Prostate Symptom Score and Quality of Life (IPSS-QoL), International Index of Erectile Function (IIEF) and Aging Males' Symptoms (AMS) scale forms. Of the patients, 23.9% had mild LUTSs, 53.3% had moderate LUTSs and 22.8% had severe LUTSs. The total testosterone level did not differ between groups. Additionally, 69.6% had ED. The presence of impotence increased with increasing LUTS severity. Symptomatic late-onset hypogonadism (AMS >27) was observed in 71.2% of the patients. The prevalence of severe hypogonadism symptoms increased with the IPSS scores. A correlation analysis revealed that all three questionnaire scores were significantly correlated. In conclusion, LUTS severity is an age-independent risk factor for ED and SLOH. LUTS severity and SLOH symptoms appear to have a strong link that requires etiological and biological clarification in future studies.
本研究旨在评估土耳其爱琴海地区老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和症状性迟发性性腺功能减退(SLOH)之间的关系。连续纳入500例年龄>40岁、过去6个月有稳定性关系且就诊于6家泌尿外科诊所之一的患者。测量血清前列腺特异性抗原、睾酮水平和尿流率。所有患者填写国际前列腺症状评分和生活质量(IPSS-QoL)、国际勃起功能指数(IIEF)和老年男性症状(AMS)量表。患者中,23.9%有轻度LUTSs,53.3%有中度LUTSs,22.8%有重度LUTSs。各组间总睾酮水平无差异。此外,69.6%有ED。阳痿的发生率随LUTS严重程度增加而升高。71.2%的患者存在症状性迟发性性腺功能减退(AMS>27)。严重性腺功能减退症状的患病率随IPSS评分增加而升高。相关性分析显示,所有三个问卷评分均显著相关。总之,LUTS严重程度是ED和SLOH的年龄无关风险因素。LUTS严重程度和SLOH症状似乎有很强的关联,需要在未来研究中进行病因学和生物学阐明。