Suazo José, Hodgson María Isabel, Obregón Ana María, Valladares Macarena, Weisstaub Gerardo, Amador Paola, Santos José Luis
J Pediatr Endocrinol Metab. 2013;26(11-12):1131-9. doi: 10.1515/jpem-2013-0084.
Metabolic syndrome (MS) related to adult type 2 diabetes mellitus and cardiovascular disease is prevalent among obese children/adolescents. Genetic variants of the leptin-melanocortin system have been associated with components of MS. The aim of our study is to estimate the prevalence of MS (according to Cook's criteria) in a Chilean cross-sectional sample of 259 obese children (47.1% girls, aged 6-12 years), and to assess the association between common genetic variants of leptin-melanocortin pathway genes (LEP, LEPR, POMC, MC3R and MC4R) with components of the MS using logistic regression. We observed an overall MS prevalence of 26.3% (32.2% in girls and 21.1% in boys) in obese Chilean children. No associations were detected between genetic variants of leptin-melanocortin genes and MS components. MS prevalence among our obese children sample is similar to those previously described in Chile, demonstrating the increased risk of diseases in adulthood that obese children carry.
与成人2型糖尿病和心血管疾病相关的代谢综合征（MS）在肥胖儿童/青少年中普遍存在。瘦素-黑皮质素系统的基因变异与MS的组成部分有关。我们研究的目的是估计在一个由259名肥胖儿童（47.1%为女孩，年龄在6至12岁之间）组成的智利横断面样本中MS（根据库克标准）的患病率，并使用逻辑回归评估瘦素-黑皮质素途径基因（LEP、LEPR、POMC MC3R和MC4R）的常见基因变异与MS组成部分之间的关联。我们观察到肥胖智利儿童的MS总体患病率为26.3%（女孩为32.2%，男孩为21.1%）。未检测到瘦素-黑皮质素基因变异与MS组成部分之间的关联。我们肥胖儿童样本中的MS患病率与智利先前描述的患病率相似，表明肥胖儿童成年后患疾病的风险增加。
