Nouel D, Dubuc I, Kitabgi P, Costentin J
Unité de Neuropsychopharmacologie expérimentale, URA 1170 du CNRS-Faculté de Médecine et Pharmacie de Rouen, Saint Etienne Rouvray, France.
Peptides. 1990 May-Jun;11(3):551-5. doi: 10.1016/0196-9781(90)90058-d.
Neurotensin injected intracerebroventricularly at the dose of 30 ng per rat was without intrinsic effect on locomotion. When associated with the enkephalinase inhibitor thiorphan (50 micrograms, intracerebroventricular) it decreased locomotor activity. On the contrary, the 3 micrograms dose of NT, which had a tendency to decrease locomotion, stimulated locomotor activity when associated with thiorphan (50 micrograms, intracerebroventricular). This effect was independent of endogenous enkephalins since it was not suppressed by a high dose of naloxone (2 mg/kg). Similarly, increasing doses of the enkephalinase-resistant peptide [D-Trp11]neurotensin had a biphasic effect on locomotion since doses lower than 60 ng were hypokinetic whereas higher doses were hyperkinetic. This latter effect was not modified by thiorphan. It was antagonized by the dopamine antagonist haloperidol (50 micrograms/kg, IP).
以每只大鼠30纳克的剂量脑室内注射神经降压素对运动没有内在影响。当与脑啡肽酶抑制剂硫磷酰胺（50微克，脑室内注射）联合使用时，它会降低运动活性。相反，3微克剂量的神经降压素虽有降低运动的倾向，但与硫磷酰胺（50微克，脑室内注射）联合使用时会刺激运动活性。这种作用与内源性脑啡肽无关，因为高剂量的纳洛酮（2毫克/千克）并不能抑制它。同样，脑啡肽酶抗性肽[D - Trp11]神经降压素剂量增加对运动有双相作用，因为低于60纳克的剂量会导致运动减少，而较高剂量则会导致运动增加。后一种作用不受硫磷酰胺影响。它可被多巴胺拮抗剂氟哌啶醇（50微克/千克，腹腔注射）拮抗。
