Inhibition of apomorphine-induced yawning and penile erection by neurotensin.

作者信息

Nouel D, Costentin J

机构信息

European Institute for Peptide Research, Unité de Neuropsychopharmacologie Expérimentale U.R.A. 1170 du C.N.R.S., Faculté de Médecine et Pharmacie de Rouen, Saint Etienne Du Rouvray, France.

出版信息

Peptides. 1991 Jul-Aug;12(4):755-9. doi: 10.1016/0196-9781(91)90129-d.

DOI:10.1016/0196-9781(91)90129-d

PMID:1788138

Abstract

The yawns and penile erection elicited in rats by apomorphine (100 micrograms/kg SC) are dose-dependently suppressed by the enkephalinase-resistant analog of NT, [D-Trp11]NT, intracerebroventricularly (ICV) injected (10-120 ng per rat). This antagonistic effect was shared by NT (0.75-3 micrograms per rat) administered ICV. The yawns induced by pilocarpine (2 mg/kg IP) were similarly antagonized by [D-Trp11]NT (30-120 ng per rat). The enkephalinase inhibitor acetorphan (5 mg/kg IV) reduced in a naloxone (2 mg/kg, SC)-resistant manner the apomorphine-induced penile erection or yawning.

摘要