[用于前列腺癌定位的扩散加权成像：癌组织与非癌组织中表观扩散系数值的比较以及根治性前列腺切除术标本的Gleason评分]

[Diffusion-weighted imaging for prostate cancer localization: comparison of apparent diffusion coefficient values in cancerous and non-cancerous tissues, and the Gleason score of the radical prostatectomy specimens].

作者信息

Kobayashi Hirohito, Kitamura Kosuke, Mizukami Sainosuke, Hanazawa Kisaburo, Sakamoto Yoshiro

机构信息

Department of Urology, Juntendo University Nerima Hospital.

出版信息

Nihon Hinyokika Gakkai Zasshi. 2013 May;104(3):489-95. doi: 10.5980/jpnjurol.104.489.

DOI:10.5980/jpnjurol.104.489

PMID:23819360

Abstract

PURPOSE

We compared magnetic resonance imaging (MRI) with radical prostatectomy specimens to evaluate the diagnostic performance of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) value for prostate cancer localization.

MATERIALS AND METHODS

We performed a retrospective study of 44 patients who underwent radical prostatectomy. We compared MRI with pathological specimens (74 tumors) to evaluate their diagnostic performance of cancer localization. The ADC value was measured in cancerous and non-cancerous prostate tissues.

RESULTS

Of 74 tumors, digital rectal examination, transrectal ultrasonography, T2-weighted imaging (T2WI), DWI, T2WI and DWI detected 9 (12.2%), 9 (12.2%), 26 (35.1%), 30 (40.5%), and 48 (64.9%) tumors, respectively. The mean ADC value was lower in cancerous tissues than in non-cancerous tissues (0.86 +/- 0.15 versus 1.24 +/- 0.16 x 10(-3) mm2/s). The mean ADC values of cancerous and non-cancerous tissues were: 0.85 +/- 0.15 versus 1.28 +/- 0.17 x 10(-3) mm2/s in the peripheral zone; and 0.87 +/- 0.15 versus 1.19 +/- 0.14 x 10(-3) mm2/s in the transition zone. The mean ADC value in patients with a Gleason score of 8 or 9 (0.76 +/- 0.12 x 10(-3) mm2/s) was lower than that in patients with a Gleason score of 6 or 7 (0.86 +/- 0.15 x 10(-3) mm2/s).

CONCLUSION

DWI and ADC value were considered to be useful for the diagnosis of prostate cancer localization.

摘要

目的

我们将磁共振成像（MRI）与前列腺癌根治术标本进行比较，以评估扩散加权成像（DWI）及表观扩散系数（ADC）值在前列腺癌定位诊断中的性能。

材料与方法

我们对44例行前列腺癌根治术的患者进行了一项回顾性研究。我们将MRI与病理标本（74个肿瘤）进行比较，以评估它们在癌症定位方面的诊断性能。在癌性和非癌性前列腺组织中测量ADC值。

结果

在74个肿瘤中，直肠指检、经直肠超声检查、T2加权成像（T2WI）、DWI、T2WI联合DWI分别检测出9个（12.2%）、9个（12.2%）、26个（35.1%）、30个（40.5%）和48个（64.9%）肿瘤。癌性组织中的平均ADC值低于非癌性组织（0.86±0.15对1.24±0.16×10⁻³mm²/s）。癌性和非癌性组织的平均ADC值分别为：外周区0.85±0.15对1.28±0.17×10⁻³mm²/s；移行区0.87±0.15对1.19±0.14×10⁻³mm²/s。Gleason评分8或9分患者的平均ADC值（0.76±0.12×10⁻³mm²/s）低于Gleason评分6或7分患者（0.86±0.15×10⁻³mm²/s）。