利用 FeCl3 介导的多米诺反应方案合成 calothrixins 及其类似物。
Synthesis of calothrixins and its analogs using FeCl3-mediated domino reaction protocol.
机构信息
Department of Organic Chemistry, School of Chemistry, University of Madras, Guindy Campus Chennai 600 025, Tamil Nadu, India.
出版信息
Org Lett. 2013 Jul 19;15(14):3726-9. doi: 10.1021/ol4015738. Epub 2013 Jul 2.
PMID:23819770
Abstract
A novel one pot synthesis of calothrixin B and its analogs is achieved involving an FeCl3-mediated domino reaction of enamines in dry DMF at reflux. Alternatively, the enamines upon interaction with CuBr2 in DMF at reflux led to the formation of 1-phenylsulfony-2-(2'-nitroaryl)-4-hydroxycarbazole-3-carbaldehydes in excellent yields.
摘要
一种新型一锅法合成 calothrixin B 及其类似物的方法，涉及在回流的干燥 DMF 中用 FeCl3 介导的烯胺的级联反应。或者，在回流的 DMF 中，烯胺与 CuBr2 相互作用可得到高产率的 1-苯磺酰基-2-(2'-硝基芳基)-4-羟基咔唑-3-甲酰。
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