Department of Civil Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia.
Chemosphere. 2013 Sep;93(2):455-9. doi: 10.1016/j.chemosphere.2013.05.013. Epub 2013 Jun 30.
In this work, the cytotoxicity and toxicity of phosphonium-based deep eutectic solvents (DESs) with three hydrogen bond donors, namely glycerine, ethylene glycol, and triethylene glycol were investigated. The cytotoxicity effect was tested using brine shrimp (Artemia salina). The toxicity was investigated using the two Gram positive bacteria Bacillus subtilis and Staphylococcus aureus, and two Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. The cytotoxicity of tested DESs was much higher than that of their individual components, indicating their toxicological behavior was different. It was also found that there was toxic effect on the studied bacteria, indicating their potential application as anti-bacterial agents. To the best of our knowledge, this is the first time the cytotoxicity and toxicity of phosphonium-based DESs were studied.
在这项工作中，研究了三种氢键供体（甘油、乙二醇和三乙二醇）的磷鎓基深共熔溶剂（DES）的细胞毒性和毒性。使用卤虫（盐水丰年虾）测试细胞毒性作用。使用两种革兰氏阳性菌枯草芽孢杆菌和金黄色葡萄球菌以及两种革兰氏阴性菌大肠杆菌和铜绿假单胞菌研究了毒性。测试的 DES 的细胞毒性远高于其各个成分的细胞毒性，表明它们的毒理学行为不同。还发现对研究中的细菌有有毒作用，表明它们有作为抗菌剂的应用潜力。据我们所知，这是首次研究磷鎓基 DES 的细胞毒性和毒性。
