Araújo Brito José, do Nascimento Marreiro Dilina, Moita Neto José Machado, Michelle Costa e Silva Danilla, Gonçalves de Sousa Almondes Kaluce, Valadares Neto João de Deus, do Nascimento Nogueira Nadir
Department of Mother and Child, Federal University of Piauí, Teresina-Piauí, Brazil.
Nutr Hosp. 2013 Mar-Apr;28(2):486-90. doi: 10.3305/nh.2013.28.2.6179.
Preeclampsia is a complex syndrome of unknown aetiologic origin. It is characterized by the clinical triad of hypertension, edema and protenuria. Current concepts of the genesis of preeclampsia include endothelial dysfunction and oxidative stress.
This study assessed the relationship between the activity of superoxide dismutase, the zincemia and the preeclampsia.
A case-control study was carried out with 94 women, age between 17 and 44 years, which were divided in two groups: women with preeclampsia (n = 44) and control group women with normal pregnancy (n = 50). The activity of superoxide dismutase enzyme was determined according to Ransod kit. Zinc concentrations in plasma and erythrocytes were determined using the flame atomic absorption spectrophotometry technique, both determined before delivery and during puerperium. Student's t-test and the paired t-test were used for statistical analysis, and significance was established at p < 0.05.
The study revealed plasma hypozincemia more pronounced in women with severe preeclampsia (p < 0.05). This behavior was not observed in erythrocytes, whose concentrations remained stable, before delivery and puerperium in women with preeclampsia and normal pregnancy. The antioxidant activity of the enzyme superoxide dismutase was found elevated in women with and without preeclampsia (p>0.05), with significant reduction in activity in the postpartum period (p < 0.05) in both groups studied (p>0.05).
This study shows there are alterations in biochemical parameters of zinc in women with preeclampsia. The activity of superoxide dismutase shows that this marker cannot be used to predict the evolution of the disease.
子痫前期是一种病因不明的复杂综合征。其特征为高血压、水肿和蛋白尿的临床三联征。目前关于子痫前期发病机制的概念包括内皮功能障碍和氧化应激。
本研究评估超氧化物歧化酶活性、锌血症与子痫前期之间的关系。
对94名年龄在17至44岁之间的女性进行了病例对照研究，将她们分为两组：子痫前期女性（n = 44）和正常妊娠对照组女性（n = 50）。根据Ransod试剂盒测定超氧化物歧化酶的活性。采用火焰原子吸收分光光度法技术测定分娩前和产褥期血浆和红细胞中的锌浓度。使用学生t检验和配对t检验进行统计分析，p < 0.05为有统计学意义。
研究显示，重度子痫前期女性的血浆低锌血症更为明显（p < 0.05）。子痫前期女性和正常妊娠女性在分娩前和产褥期红细胞中的锌浓度保持稳定，未观察到这种情况。发现子痫前期女性和非子痫前期女性的超氧化物歧化酶抗氧化活性均升高（p>0.05），在研究的两组中产后活性均显著降低（p < 0.05）（p>0.05）。
本研究表明子痫前期女性的锌生化参数存在改变。超氧化物歧化酶的活性表明该标志物不能用于预测疾病的进展。
