Kalaitzidou I, Venetikou M S, Konstadinidis K, Artemiadis A K, Chrousos G, Darviri C
Postgraduate Course Stress Management and Health Promotion, School of Medicine, University of Athens at Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Andrologia. 2014 Aug;46(6):698-702. doi: 10.1111/and.12129. Epub 2013 Jul 3.
Erectile dysfunction (ED) is a complex disorder with various biopsychosocial implications leading the individual into a state of chronic stress that further worsens ED symptoms. The aim of this study is to investigate the effects of a 8-week stress management programme on erectile dysfunction (ED). A convenience sample of 31 newly diagnosed men with ED, aged between 20 and 55 years, was recruited during a period of 5 months to receive either tadalafil (12 patients) or tadalafil and the 8-week stress management programme. Both groups showed statistical significant improvement of both perceived stress and erectile function scores. Men practising stress management showed a statistical significant reduction in perceived stress score compared with men receiving tadalafil alone. No other statistical significant differences were noted between the two groups, although the stress management group showed a lower daily exposure to cortisol compared with the control group after 8 weeks. Finally, perceived stress and cortisol showed some interesting correlations with sexual function measurements. These findings provide important insight into the role of stress management, as part of the recommended biopsychosocial approach, in ED. Future studies should focus on randomised, controlled trials with larger samples and longer follow-up time.
勃起功能障碍（ED）是一种复杂的疾病，具有多种生物心理社会学影响，导致个体进入慢性应激状态，进而使ED症状进一步恶化。本研究的目的是调查为期8周的压力管理计划对勃起功能障碍（ED）的影响。在5个月的时间里，招募了31名年龄在20至55岁之间新诊断为ED的男性作为便利样本，他们被分为两组，一组接受他达拉非治疗（12名患者），另一组接受他达拉非及为期8周的压力管理计划。两组在感知压力和勃起功能评分方面均有统计学上的显著改善。与仅接受他达拉非治疗的男性相比，实施压力管理的男性在感知压力评分上有统计学上的显著降低。两组之间未发现其他统计学上的显著差异，尽管8周后压力管理组与对照组相比，每日皮质醇暴露量较低。最后，感知压力和皮质醇与性功能测量结果呈现出一些有趣的相关性。这些发现为压力管理作为推荐的生物心理社会学方法的一部分在ED中的作用提供了重要见解。未来的研究应聚焦于样本量更大、随访时间更长的随机对照试验。
