Testa M, Raffe M R, Robinson E P
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
Vet Surg. 1990 Jul-Aug;19(4):308-12. doi: 10.1111/j.1532-950x.1990.tb01194.x.
Twenty-five percent, 50%, and 67% nitrous oxide was administered to 12 horses anesthetized with halothane and oxygen. Compared to halothane-oxygen alone, there was no significant difference in heart rate, systolic, diastolic, or mean blood pressure values, arterial pH, PaCO2, or plasma bicarbonate values when nitrous oxide was included. A significant linear reduction in PaO2 values could be correlated with N2O:O2 concentrations. The halothane level required to maintain surgical anesthesia was reduced when nitrous oxide was administered, but it was not affected by changing the nitrous oxide concentrations. Nitrous oxide concentrations greater than 25% provide no additional reduction in halothane requirement and may be accompanied by PaO2 values that pose risk to the horse.
向12匹用氟烷和氧气麻醉的马分别给予25%、50%和67%的氧化亚氮。与单纯使用氟烷 - 氧气相比，加入氧化亚氮时，心率、收缩压、舒张压或平均血压值、动脉pH值、动脉血二氧化碳分压（PaCO2）或血浆碳酸氢盐值均无显著差异。动脉血氧分压（PaO2）值的显著线性降低与氧化亚氮与氧气的浓度相关。给予氧化亚氮时，维持手术麻醉所需的氟烷水平降低，但不受氧化亚氮浓度变化的影响。氧化亚氮浓度大于25%时，氟烷需求量不会进一步降低，且可能伴随着对马有风险的PaO2值。
