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通过电润湿液滴喷射制备单分散且可调节的生物可降解聚合物载药微球：尺寸、形状和药物释放控制。

Microencapsulation of chemotherapeutics into monodisperse and tunable biodegradable polymers via electrified liquid jets: control of size, shape, and drug release.

机构信息

Departments of Bioengineering and Chemical Engineering, Pennsylvania State University, University Park, PA 16802, USA.

出版信息

Adv Mater. 2013 Sep 6;25(33):4555-60. doi: 10.1002/adma.201301033. Epub 2013 Jul 4.

DOI:10.1002/adma.201301033
PMID:23824544
Abstract

This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods.

摘要

本文采用电喷射技术，将抗肿瘤药物 1,3-双(2-氯乙基)-1-亚硝基脲（BCNU，卡莫司汀）包封入可生物降解聚合物聚乳酸-共-羟基乙酸（PLGA）中。与其他包封方法相比，所得载 BCNU 的 PLGA 微胶囊具有更高的药物包封效率、更可调的载药能力和更窄的粒径分布。

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