Almers W
Philos Trans R Soc Lond B Biol Sci. 1975 Jun 10;270(908):507-13. doi: 10.1098/rstb.1975.0027.
Using signal-averaging techniques, one can record small membrane currents which remain even after blockage of the ionic currents which accompany electrical excitation in muscle. These residual currents probably represent the reorientation of charged molecules inside the membrane in response to a change in membrane potential. Two operationally separable types of intramembrane charge movement in muscle are described, one of which may play a role in excitation-contraction coupling. Studies of tetrodotoxin binding to muscle indicate that "sodium gating current" is unlikely to contribute significantly to either type of charge movement.
运用信号平均技术，人们能够记录到微小的膜电流，即便在伴随肌肉电兴奋的离子电流被阻断之后，这些电流依然存在。这些残余电流可能代表着膜内带电分子响应膜电位变化而发生的重新定向。本文描述了肌肉中两种在操作上可分离的膜内电荷移动类型，其中一种可能在兴奋-收缩偶联中发挥作用。对河豚毒素与肌肉结合的研究表明，“钠门控电流”不太可能对这两种电荷移动类型有显著贡献。
