Zehender M, Meinertz T, Hohnloser S, Geibel A, Brugada P, Waldecker B, Just H
Innere Medizin III, Universitätsklinik Freiburg.
Z Kardiol. 1990 May;79(5):374-9.
In contrast to patients with organic heart disease, there are only few data available on the incidence and type of inducible arrhythmias during programmed electrical stimulation (PES) in patients with spontaneous ventricular tachycardia (VT) but without evidence of underlying heart disease. Additionally, no consensus has been achieved in these patients on the most appropriate stimulation protocol required to reproduce the clinical arrhythmia. In a prospective study we analyzed in 40 patients without idiopathic VT, incidence and type of inducible VT, as well as the mode of initiation during a right ventricular PES protocol with 1-2 (part I) and three extrastimuli (part II). Twelve patients had spontaneous sustained monomorphic VT (group A), 28 patients were studied with spontaneous non-sustained VT (group B). During PES, a non-sustained polymorphic VT was induced in 3/12 patients (group A, 25%) and in 10/28 patients (group B, 36%); a non-sustained monomorphic VT was induced in 5/12 patients (group A, 41%) and in 4/28 patients (group B, 14%). In all 7/12 patients (59%) of group A with inducible sustained monomorphic VT, the arrhythmia was initiated with 1-2 extrastimuli. In group B, only 2/28 patients (7%) were induced to a sustained monomorphic VT. When the clinical arrhythmia was exercise-related, 5/6 patients (83%) in group A and 7/13 patients (54%) in group B were induced to a VT, while 2/6 patients (33%) in group A and 1/13 (8%) patients in group B were induced to a sustained monomorphic VT. Isoprenaline was not effective to increase the incidence of sustained monomorphic VT.(ABSTRACT TRUNCATED AT 250 WORDS)
与患有器质性心脏病的患者相比,关于无潜在心脏病证据但有自发性室性心动过速(VT)的患者在程控电刺激(PES)期间可诱发心律失常的发生率及类型的数据很少。此外,对于这些患者重现临床心律失常所需的最合适刺激方案尚未达成共识。在一项前瞻性研究中,我们分析了40例无特发性VT的患者,在采用1 - 2个(第一部分)和3个期外刺激(第二部分)的右心室PES方案期间,可诱发VT的发生率及类型,以及诱发方式。12例患者有自发性持续性单形性VT(A组),28例患者有自发性非持续性VT(B组)。在PES期间,3/12例患者(A组,25%)和10/28例患者(B组,36%)诱发了非持续性多形性VT;5/12例患者(A组,41%)和4/28例患者(B组,14%)诱发了非持续性单形性VT。在A组所有7/12例(59%)可诱发持续性单形性VT的患者中,心律失常由1 - 2个期外刺激诱发。在B组,仅2/28例患者(7%)诱发了持续性单形性VT。当临床心律失常与运动相关时,A组5/6例患者(83%)和B组7/13例患者(54%)诱发了VT,而A组2/6例患者(33%)和B组1/13例患者(8%)诱发了持续性单形性VT。异丙肾上腺素对增加持续性单形性VT的发生率无效。(摘要截选至250词)