侵袭性真菌感染的小鼠模型

Mouse model of invasive fungal infection.

作者信息

MacCallum Donna M

机构信息

Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.

出版信息

Methods Mol Biol. 2013;1031:145-53. doi: 10.1007/978-1-62703-481-4_17.

DOI:10.1007/978-1-62703-481-4_17

PMID:23824897

Abstract

The mouse intravenous (IV) challenge model of Candida albicans invasive fungal infection has been widely used to study the importance of the innate immune system in these infections. This chapter describes this well-characterized model, where fungal cells are administered directly into the mouse bloodstream to initiate a systemic infection. The preparation of tissue samples from infected mice to allow evaluation of disease progression and host responses is also described.

摘要

白色念珠菌侵袭性真菌感染的小鼠静脉内（IV）攻击模型已被广泛用于研究固有免疫系统在这些感染中的重要性。本章描述了这个特征明确的模型，即将真菌细胞直接注入小鼠血液中以引发全身感染。还介绍了从感染小鼠制备组织样本以评估疾病进展和宿主反应的方法。