• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

口服液体 L-甲状腺素（L-T4）可能比 L-T4 片剂在减重手术后更易吸收。

Oral liquid L-thyroxine (L-t4) may be better absorbed compared to L-T4 tablets following bariatric surgery.

机构信息

Department of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, Clinica Medica, University of Brescia, 1 Medicina Spedali Civili di Brescia, Piazzale Spedali Civili n1, 25100 Brescia, Italy.

出版信息

Obes Surg. 2013 Sep;23(9):1493-6. doi: 10.1007/s11695-013-1015-y.

DOI:10.1007/s11695-013-1015-y
PMID:23824980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3726924/
Abstract

Drug malabsorption is a potential concern after bariatric surgery. We present four case reports of hypothyroid patients who were well replaced with thyroxine tablets to euthyroid thyrotropin (TSH) levels prior to Roux-en-Y gastric bypass surgery. These patients developed elevated TSH levels after the surgery, the TSH responded reversibly to switching from treatment with oral tablets to a liquid formulation.

摘要

药物吸收不良是减肥手术后的一个潜在问题。我们报告了 4 例甲状腺功能减退症患者的病例，这些患者在接受 Roux-en-Y 胃旁路手术前，通过服用甲状腺素片将甲状腺素刺激素（TSH）水平调整到正常范围。这些患者在手术后出现了 TSH 水平升高，将口服片剂改为液体制剂后 TSH 水平可逆转恢复正常。

相似文献

1
Oral liquid L-thyroxine (L-t4) may be better absorbed compared to L-T4 tablets following bariatric surgery.口服液体 L-甲状腺素（L-T4）可能比 L-T4 片剂在减重手术后更易吸收。
Obes Surg. 2013 Sep;23(9):1493-6. doi: 10.1007/s11695-013-1015-y.
2
TSH Normalization in Bariatric Surgery Patients After the Switch from L-Thyroxine in Tablet to an Oral Liquid Formulation.肥胖症手术患者从左甲状腺素片剂转换为口服液体制剂后的促甲状腺激素正常化
Obes Surg. 2017 Jan;27(1):78-82. doi: 10.1007/s11695-016-2247-4.
3
IN PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM WHILE IN THERAPY WITH TABLET L-T4, THE LIQUID L-T4 FORMULATION IS MORE EFFECTIVE IN RESTORING EUTHYROIDISM.在接受左旋甲状腺素片治疗的亚临床甲状腺功能减退症患者中，液体左旋甲状腺素制剂在恢复甲状腺功能正常方面更有效。
Endocr Pract. 2017 Feb;23(2):170-174. doi: 10.4158/EP161545.OR. Epub 2016 Nov 16.
4
Reversible normalisation of serum TSH levels in patients with autoimmune atrophic gastritis who received L-T4 in tablet form after switching to an oral liquid formulation: a case series.自身免疫性萎缩性胃炎患者从片剂形式的左甲状腺素（L-T4）转换为口服液体制剂后血清促甲状腺激素（TSH）水平的可逆性正常化：病例系列
BMC Gastroenterol. 2016 Feb 24;16:22. doi: 10.1186/s12876-016-0439-y.
5
Oral L-thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study.左甲状腺素口服液与片剂用于无吸收不良的甲状腺功能减退患者：一项前瞻性研究。
Endocrine. 2016 Jun;52(3):597-601. doi: 10.1007/s12020-015-0836-y. Epub 2015 Dec 31.
6
Advancements in the treatment of hypothyroidism with L-T4 liquid formulation or soft gel capsule: an update.左甲状腺素液体剂型或软胶囊治疗甲状腺功能减退症的进展：最新情况
Expert Opin Drug Deliv. 2017 May;14(5):647-655. doi: 10.1080/17425247.2016.1227782. Epub 2016 Aug 30.
7
L-T4 Therapy in Enteric Malabsorptive Disorders.肠吸收不良性疾病的 L-T4 治疗。
Front Endocrinol (Lausanne). 2021 Feb 23;12:626371. doi: 10.3389/fendo.2021.626371. eCollection 2021.
8
Levothyroxine absorption in morbidly obese patients before and after Roux-En-Y gastric bypass (RYGB) surgery.肥胖症患者罗伊思-恩-耶胃旁路（RYGB）手术前后左甲状腺素钠的吸收。
Obes Surg. 2012 Feb;22(2):253-8. doi: 10.1007/s11695-011-0452-8.
9
[Bioequivalence of L-thyroxine tablets and a liquid L-thyroxine solution in the treatment of hypothyroid patients].[左甲状腺素片与左甲状腺素液体制剂治疗甲状腺功能减退患者的生物等效性]
Med Klin (Munich). 2004 Nov 15;99(11):639-44. doi: 10.1007/s00063-004-1096-4.
10
Lactose intolerance and levothyroxine malabsorption: a review of the literature and report of a series of patients treated with liquid L-T4 without lactose.乳糖不耐受和左甲状腺素吸收不良：文献复习及一组用不含乳糖的液体 L-T4 治疗的患者报告。
Front Endocrinol (Lausanne). 2024 Apr 11;15:1386510. doi: 10.3389/fendo.2024.1386510. eCollection 2024.

引用本文的文献

1
Are liquid levothyroxine formulations comparable? The LETI study.液体左甲状腺素制剂是否具有可比性？LETI研究。
Thyroid Res. 2025 Apr 24;18(1):17. doi: 10.1186/s13044-025-00236-9.
2
Levothyroxine malabsorption following sleeve gastrectomy.袖状胃切除术后左甲状腺素吸收不良
Endocrinol Diabetes Metab Case Rep. 2025 Jan 27;2025(1). doi: 10.1530/EDM-24-0115. Print 2025 Jan 1.
3
Myxedema coma secondary to levothyroxine malabsorption in a patient previously submitted to bariatric surgery.患者曾行减重手术，现因左甲状腺素吸收不良导致黏液性水肿性昏迷。
Arch Endocrinol Metab. 2024 Feb 19;68:e230095. doi: 10.20945/2359-4292-2023-0095. eCollection 2024.
4
Liquid L-T4 therapy in hypothyroid patients with gastric diseases, an observational study.甲状腺功能减退症伴胃病患者的液体 L-T4 治疗：一项观察性研究。
Front Endocrinol (Lausanne). 2024 Jul 4;15:1386629. doi: 10.3389/fendo.2024.1386629. eCollection 2024.
5
Impact of Bariatric Surgery in the Short and Long Term: A Need for Time-Dependent Dosing of Drugs.减重手术的短期和长期影响：药物需要随时间调整剂量。
Obes Surg. 2023 Oct;33(10):3266-3302. doi: 10.1007/s11695-023-06770-5. Epub 2023 Aug 18.
6
Medications and Food Interfering with the Bioavailability of Levothyroxine: A Systematic Review.影响左甲状腺素生物利用度的药物与食物：一项系统评价
Ther Clin Risk Manag. 2023 Jun 23;19:503-523. doi: 10.2147/TCRM.S414460. eCollection 2023.
7
The performance of levothyroxine tablet is impaired by bariatric surgery.左甲状腺素片的疗效会受到减重手术的影响。
Endocrine. 2023 Jun;80(3):563-569. doi: 10.1007/s12020-022-03289-0. Epub 2022 Dec 29.
8
Liquid levothyroxine formulations in patients taking drugs interfering with L-T4 absorption.正在服用影响 L-T4 吸收的药物的患者使用液体左甲状腺素制剂。
Front Endocrinol (Lausanne). 2022 Dec 6;13:1080108. doi: 10.3389/fendo.2022.1080108. eCollection 2022.
9
Prevalence of Lactose Intolerance in Patients with Hashimoto Thyroiditis and Impact on LT4 Replacement Dose.桥本甲状腺炎患者乳糖不耐受的患病率及其对 LT4 替代剂量的影响。
Nutrients. 2022 Jul 22;14(15):3017. doi: 10.3390/nu14153017.
10
It's Not Lupus This Time! A Case of Worsening Hypothyroidism in a Patient With Nephrotic Syndrome.这次不是狼疮！一例肾病综合征患者甲状腺功能减退加重的病例。
Cureus. 2022 May 26;14(5):e25355. doi: 10.7759/cureus.25355. eCollection 2022 May.

本文引用的文献

1
Approach to and treatment of differentiated thyroid carcinoma.分化型甲状腺癌的诊治方法。
Med Clin North Am. 2012 Mar;96(2):369-83. doi: 10.1016/j.mcna.2012.01.002. Epub 2012 Feb 10.
2
Hypothyroidism: etiology, diagnosis, and management.甲状腺功能减退症：病因、诊断与治疗。
Med Clin North Am. 2012 Mar;96(2):203-21. doi: 10.1016/j.mcna.2012.01.005. Epub 2012 Feb 14.
3
Levothyroxine absorption in morbidly obese patients before and after Roux-En-Y gastric bypass (RYGB) surgery.肥胖症患者罗伊思-恩-耶胃旁路（RYGB）手术前后左甲状腺素钠的吸收。
Obes Surg. 2012 Feb;22(2):253-8. doi: 10.1007/s11695-011-0452-8.
4
A systematic review of drug absorption following bariatric surgery and its theoretical implications.减重手术后药物吸收的系统评价及其理论意义。
Obes Rev. 2010 Jan;11(1):41-50. doi: 10.1111/j.1467-789X.2009.00614.x. Epub 2009 Jun 2.
5
Altered intestinal absorption of L-thyroxine caused by coffee.咖啡导致L-甲状腺素的肠道吸收改变。
Thyroid. 2008 Mar;18(3):293-301. doi: 10.1089/thy.2007.0222.
6
L-thyroxine requirement in patients with autoimmune hypothyroidism and parietal cell antibodies.自身免疫性甲状腺功能减退症和壁细胞抗体患者的左甲状腺素需求量
J Clin Endocrinol Metab. 2008 Feb;93(2):465-9. doi: 10.1210/jc.2007-1544. Epub 2007 Nov 27.
7
Bariatric surgery trends: an 18-year report from the International Bariatric Surgery Registry.减肥手术趋势：来自国际减肥手术注册中心的18年报告。
Am J Surg. 2006 Nov;192(5):657-62. doi: 10.1016/j.amjsurg.2006.07.006.
8
Medication and nutrient administration considerations after bariatric surgery.减肥手术后的药物和营养管理注意事项。
Am J Health Syst Pharm. 2006 Oct 1;63(19):1852-7. doi: 10.2146/ajhp060033.
9
Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis.甲状腺肿中的甲状腺素、幽门螺杆菌感染与慢性胃炎
N Engl J Med. 2006 Apr 27;354(17):1787-95. doi: 10.1056/NEJMoa043903.
10
Oral mucosal drug delivery: clinical pharmacokinetics and therapeutic applications.口腔黏膜给药：临床药代动力学与治疗应用。
Clin Pharmacokinet. 2002;41(9):661-80. doi: 10.2165/00003088-200241090-00003.