• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

白三烯 D4 和乙酰甲胆碱反应性预测孟鲁司特治疗哮喘的疗效。

Responsiveness to leukotriene D4 and methacholine for predicting efficacy of montelukast in asthma.

机构信息

State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China;

出版信息

J Thorac Dis. 2013 Jun;5(3):298-301. doi: 10.3978/j.issn.2072-1439.2013.02.01.

DOI:10.3978/j.issn.2072-1439.2013.02.01
PMID:23825762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3698267/
Abstract

A lower responsiveness to leukotriene D4 (LTD4) or higher LTD4/[methacholine (MCh)] potency ratio might suggest preferable outcomes of short-term montelukast monotherapy in terms of airway inflammation and lung function in asthmatic patients.

摘要

在哮喘患者中，对白细胞三烯 D4（LTD4）的反应性降低或 LTD4/[乙酰甲胆碱（MCh）]效价比升高，可能提示短期单独使用孟鲁司特治疗在气道炎症和肺功能方面具有更好的效果。

相似文献

1
Responsiveness to leukotriene D4 and methacholine for predicting efficacy of montelukast in asthma.白三烯 D4 和乙酰甲胆碱反应性预测孟鲁司特治疗哮喘的疗效。
J Thorac Dis. 2013 Jun;5(3):298-301. doi: 10.3978/j.issn.2072-1439.2013.02.01.
2
Responsiveness to methacholine, but not leukotriene D4, correlates with fractional exhaled nitric oxide in asthma.在哮喘中，对乙酰甲胆碱而非白三烯D4的反应性与呼出一氧化氮分数相关。
Clin Respir J. 2016 Mar;10(2):176-80. doi: 10.1111/crj.12199. Epub 2014 Sep 3.
3
[Leukotriene D4 bronchial provocation test for detection of airway hyper-responsiveness in children].[白三烯D4支气管激发试验用于检测儿童气道高反应性]
Nan Fang Yi Ke Da Xue Xue Bao. 2020 Jun 30;40(6):793-798. doi: 10.12122/j.issn.1673-4254.2020.06.04.
4
Leukotriene D4 inhalation challenge for predicting short-term efficacy of montelukast: a pilot study.白三烯D4吸入激发试验预测孟鲁司特短期疗效：一项初步研究
Clin Respir J. 2015 Jan;9(1):111-20. doi: 10.1111/crj.12117. Epub 2014 Mar 5.
5
Relation between bronchial responsiveness to inhaled leukotriene D4 and markers of leukotriene biosynthesis.支气管对吸入白三烯D4的反应性与白三烯生物合成标志物之间的关系
Thorax. 2005 Nov;60(11):902-8. doi: 10.1136/thx.2005.041913. Epub 2005 Jul 29.
6
Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes.白细胞三烯 D4 和乙酰甲胆碱支气管激发试验用于鉴定白细胞三烯反应性亚型。
J Allergy Clin Immunol. 2013 Feb;131(2):332-8.e1-4. doi: 10.1016/j.jaci.2012.08.020. Epub 2012 Oct 4.
7
Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects.吸入白三烯D4对哮喘患者气道嗜酸性粒细胞增多及气道高反应性的影响。
Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1562-7. doi: 10.1164/ajrccm.159.5.9810095.
8
Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication.吸入性孟鲁司特抑制卵清蛋白致敏豚鼠半胱氨酰白三烯诱导的支气管收缩：作为一种新型哮喘药物的潜力。
Int Immunopharmacol. 2009 Oct;9(11):1337-41. doi: 10.1016/j.intimp.2009.08.007. Epub 2009 Aug 23.
9
The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma.吸入白三烯D4和乙酰甲胆碱对哮喘患者痰液细胞分类的影响。
Am J Respir Crit Care Med. 1997 Apr;155(4):1247-53. doi: 10.1164/ajrccm.155.4.9105062.
10
Asthmatic airways have a disproportionate hyperresponsiveness to LTE4, as compared with normal airways, but not to LTC4, LTD4, methacholine, and histamine.与正常气道相比，哮喘气道对白三烯E4具有不成比例的高反应性，但对白三烯C4、白三烯D4、乙酰甲胆碱和组胺则不然。
Am Rev Respir Dis. 1990 Nov;142(5):1112-8. doi: 10.1164/ajrccm/142.5.1112.

引用本文的文献

1
Advances in respiratory physiology in mouse models of experimental asthma.实验性哮喘小鼠模型中呼吸生理学的进展。
Front Physiol. 2023 Mar 16;14:1099719. doi: 10.3389/fphys.2023.1099719. eCollection 2023.
2
Cyclophilin A Plays Potential Roles in a Rat Model of Asthma and Suppression of Immune Response.亲环素A在哮喘大鼠模型及免疫反应抑制中发挥潜在作用。
J Asthma Allergy. 2021 May 7;14:471-480. doi: 10.2147/JAA.S308938. eCollection 2021.
3
Response--dose ratio is a surrogate of cumulative provocative dosage for bronchial provocation tests in asthma.反应-剂量比是哮喘支气管激发试验中累积激发剂量的替代指标。
Lung. 2014 Oct;192(5):701-9. doi: 10.1007/s00408-014-9612-7. Epub 2014 Jun 24.

本文引用的文献

1
Leukotriene D4 and methacholine bronchial provocation tests for identifying leukotriene-responsiveness subtypes.白细胞三烯 D4 和乙酰甲胆碱支气管激发试验用于鉴定白细胞三烯反应性亚型。
J Allergy Clin Immunol. 2013 Feb;131(2):332-8.e1-4. doi: 10.1016/j.jaci.2012.08.020. Epub 2012 Oct 4.
2
Leukotriene D4 bronchial provocation test: methodology and diagnostic value.白三烯 D4 支气管激发试验：方法学和诊断价值。
Curr Med Res Opin. 2012 May;28(5):797-803. doi: 10.1185/03007995.2012.678936. Epub 2012 May 3.
3
Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma.尿白三烯 E4/呼出气一氧化氮比值与孟鲁司特钠在儿童哮喘中的反应。
J Allergy Clin Immunol. 2010 Sep;126(3):545-51.e1-4. doi: 10.1016/j.jaci.2010.07.008.
4
A clinical trial of the efficacy and safety of montelukast as monotherapy in patients with chronic stable bronchial asthma.孟鲁司特作为慢性稳定型支气管哮喘患者单一疗法的疗效和安全性的临床试验。
J Indian Med Assoc. 2004 Feb;102(2):109-11.
5
Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078).半胱氨酰白三烯受体拮抗剂（普仑司特；ONO-1078）对人嗜酸性粒细胞活化的抑制作用。
J Asthma. 2003 Jun;40(4):395-404. doi: 10.1081/jas-120018709.
6
Correlation between cysteinyl leukotriene release from leukocytes and clinical response to a leukotriene inhibitor.白细胞中半胱氨酰白三烯释放与白三烯抑制剂临床反应之间的相关性
Chest. 2002 Nov;122(5):1566-70. doi: 10.1378/chest.122.5.1566.
7
Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999.成人及儿童呼出的下呼吸道一氧化氮和鼻腔一氧化氮在线及离线测量标准化程序的建议 - 1999年。本美国胸科学会官方声明于1999年7月被ATS董事会采纳。
Am J Respir Crit Care Med. 1999 Dec;160(6):2104-17. doi: 10.1164/ajrccm.160.6.ats8-99.
8
Leukotrienes as mediators of airway obstruction.白三烯作为气道阻塞的介质。
Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 3):S193-200. doi: 10.1164/ajrccm.158.supplement_2.13tac180.