睡眠中脱毒酒精依赖男性的心率变异性：与健康对照的比较。
Heart rate variability during sleep in detoxified alcohol-dependent males: A comparison with healthy controls.
机构信息
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
出版信息
Indian J Psychiatry. 2013 Apr;55(2):173-7. doi: 10.4103/0019-5545.111458.
CONTEXT
Alcohol dependence can lead to autonomic neuropathy resulting in increased cardiac morbidity and mortality. This has previously been evaluated using heart-rate variability.
AIMS
We compared sleep heart-rate variability of alcohol-dependent patients with that of healthy controls in this study.
SETTINGS AND DESIGN
This study was conducted at NIMHANS, Bangalore. A case control study design was adopted.
MATERIALS AND METHODS
Sleep heart-rate variability of 20 male alcohol-dependent inpatients was recorded on the 5(th) day after detoxification. Sleep heart-rate variability was also recorded in 18 age- and gender-matched healthy controls.
STATISTICAL ANALYSIS
The groups were compared using t-test for continuous variables and Chi-squared test for discrete variables.
RESULTS
Both time and frequency domain measures were significantly lower in the patients as compared to the controls, indicating decreased HRV in alcohol-dependent individuals.
CONCLUSIONS
Decreased HRV in alcohol dependence indicates potential autonomic neuropathy.
背景
酒精依赖可导致自主神经病变，从而增加心脏发病率和死亡率。这在以前是通过心率变异性评估的。
目的
本研究比较了酒精依赖患者和健康对照者的睡眠心率变异性。
设置和设计
这项研究是在班加罗尔的国家精神卫生和神经科学研究所进行的。采用病例对照研究设计。
材料和方法
20 名男性酒精依赖住院患者在戒酒后的第 5 天记录睡眠心率变异性。还记录了 18 名年龄和性别匹配的健康对照者的睡眠心率变异性。
统计分析
使用 t 检验比较连续变量，使用卡方检验比较离散变量。
结果
与对照组相比，患者的时间和频率域指标均显著降低，表明酒精依赖个体的心率变异性降低。
结论
酒精依赖时心率变异性降低表明可能存在自主神经病变。
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