酒精依赖综合征：心率变异性的体位挑战。
Alcohol-dependence syndrome: Postural challenge on heart rate variability.
机构信息
Human Physiological Laboratory, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, Karnataka, India ; Department of Physiology, St. John's Medical College, Bangalore, Karnataka, India.
出版信息
Indian J Psychiatry. 2012 Jul;54(3):253-6. doi: 10.4103/0019-5545.102426.
BACKGROUND
Cardiac autonomic involvement in Alcohol-Dependence Syndrome (ADS) patients has been demonstrated using conventional autonomic tests. Resting heart rate variability (HRV) without normalization has also been reported.
AIMS
To evaluate cardiac autonomic changes with postural challenge using HRV in ADS and controls while controlling for confounding factors.
SETTINGS AND DESIGN
Cross-sectional study involving 27 male subjects with ADS and age-matched healthy controls.
MATERIALS AND METHODS
Clinical assessments included Schedules for Clinical Assessment in Neuropsychiatry and Severity of Alcohol Dependence Questionnaire. Spectral measures of HRV while lying and with active standing were assessed.
RESULTS
There was an attenuated response in delta high-frequency (P=0.06) and delta low-frequency (P=0.04) power to standing in ADS subjects compared with controls.
CONCLUSION
Patients with ADS appear to have attenuated cardiac vagal and sympathetic responses to standing. HRV with postural challenge may help earlier recognition of autonomic dysfunction in ADS.
背景
使用常规自主神经测试已经证明了酒精依赖综合征（ADS）患者的心脏自主神经参与。也有报道称，未进行正常化的静息心率变异性（HRV）。
目的
通过 HRV 在 ADS 和对照组中评估体位挑战时的心脏自主神经变化，同时控制混杂因素。
设置和设计
涉及 27 名男性 ADS 患者和年龄匹配的健康对照组的横断面研究。
材料和方法
临床评估包括神经精神病学临床评估时间表和酒精依赖严重程度问卷。评估了卧位和主动站立时 HRV 的频谱测量。
结果
与对照组相比，ADS 受试者的高频（P=0.06）和低频（P=0.04）功率对站立的反应减弱。
结论
ADS 患者的心脏迷走神经和交感神经对站立的反应似乎减弱。体位挑战时的 HRV 可能有助于更早识别 ADS 中的自主神经功能障碍。
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