Yorioka N, Hirabayashi A, Kanahara K, Takemasa A, Oda H, Joarder Z H, Yamakido M
Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Am J Nephrol. 1990;10(3):181-5. doi: 10.1159/000168078.
Serum soluble interleukin-2 receptor (IL-2R) concentrations were determined using the ELISA method in 55 cases of glomerulonephritis. These patients can be classified as 29 cases of IgA nephropathy, 10 cases of membranous glomerulonephritis and 16 cases of mesangial proliferative glomerulonephritis. Our results showed that serum soluble IL-2R concentrations in glomerulonephritis cases were significantly higher than those in healthy controls. Among the different types of glomerulonephritis cases, however, no significant differences in serum soluble IL-2R were observed. While we found a significant positive correlation of serum soluble IL-2R to BUN and creatinine, we also found a significant negative correlation between serum soluble IL-2R and creatinine clearance. These findings suggest that serum soluble IL-2R can serve as an indicator of exacerbation of glomerulonephritis.
采用酶联免疫吸附测定（ELISA）法测定了55例肾小球肾炎患者血清可溶性白细胞介素-2受体（IL-2R）浓度。这些患者可分为29例IgA肾病、10例膜性肾小球肾炎和16例系膜增生性肾小球肾炎。我们的结果显示，肾小球肾炎患者血清可溶性IL-2R浓度显著高于健康对照组。然而，在不同类型的肾小球肾炎病例中，未观察到血清可溶性IL-2R有显著差异。虽然我们发现血清可溶性IL-2R与血尿素氮（BUN）和肌酐呈显著正相关，但也发现血清可溶性IL-2R与肌酐清除率呈显著负相关。这些发现表明，血清可溶性IL-2R可作为肾小球肾炎病情加重的一个指标。
