CTSZ rs34069356 和 MC3R rs6127698 基因多态性与肺结核的关联。
Association of CTSZ rs34069356 and MC3R rs6127698 gene polymorphisms with pulmonary tuberculosis.
机构信息
Cellular and Molecular Research Centre, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Int J Tuberc Lung Dis. 2013 Sep;17(9):1224-8. doi: 10.5588/ijtld.12.0762. Epub 2013 Jul 3.
OBJECTIVE
To evaluate the possible association between cathepsin Z (CTSZ) rs34069356 C/T (Ala286Thr) and melanocortin-3 receptor (MC3R) rs6127698 G>T (-484 G/T) gene polymorphisms and pulmonary tuberculosis (PTB) in an Iranian sample population.
DESIGN
This case-control study included 150 PTB patients and 177 healthy subjects. Tetra amplification refractory mutation system-polymerase chain reaction was used to detect polymorphisms.
RESULTS
Our findings revealed that the MC3R rs6127698 TT genotype increased the risk of PTB compared with GG (additive model: OR 2.24, 95%CI 1.13-4.64, P = 0.021) as well as GG+GT (recessive model: OR 1.89, 95%CI 1.13-3.18, P = 0.016). The rs6127698 T allele increased the risk of PTB (OR 1.56, 95%CI 1.14-2.13, P = 0.005) compared to the G allele. The CTSZ rs34069356 polymorphism was not associated with PTB in additive-, dominant- and recessive-tested inheritance models (P > 0.05).
CONCLUSION
Our data suggest that MC3R rs6127698, but not CTSZ rs34069356 polymorphism, is associated with PTB in a sample Iranian population.
目的
评估组织蛋白酶 Z（CTSZ）rs34069356 C/T（Ala286Thr）和黑素皮质素-3 受体（MC3R）rs6127698 G>T（-484 G/T）基因多态性与伊朗人群肺结核（PTB）之间可能存在的关联。
设计
这项病例对照研究纳入了 150 例肺结核患者和 177 例健康对照。采用四引物扩增受阻突变系统-聚合酶链反应检测多态性。
结果
我们的研究结果表明，与 GG 基因型相比，MC3R rs6127698 TT 基因型增加了患肺结核的风险（加性模型：OR 2.24，95%CI 1.13-4.64，P=0.021），以及 GG+GT 基因型（隐性模型：OR 1.89，95%CI 1.13-3.18，P=0.016）。与 G 等位基因相比，rs6127698 T 等位基因增加了患肺结核的风险（OR 1.56，95%CI 1.14-2.13，P=0.005）。CTSZ rs34069356 多态性在加性、显性和隐性遗传模型中与肺结核均无关联（P＞0.05）。
结论
我们的数据表明，MC3R rs6127698 而不是 CTSZ rs34069356 多态性与伊朗人群肺结核有关。
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