CD209 启动子-336A/G（rs4804803）多态性与伊朗东南部扎黑丹地区肺结核易感性相关。

CD209 promoter -336 A/G (rs4804803) polymorphism is associated with susceptibility to pulmonary tuberculosis in Zahedan, southeast Iran.

机构信息

Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

出版信息

J Microbiol Immunol Infect. 2014 Jun;47(3):171-5. doi: 10.1016/j.jmii.2013.03.013. Epub 2013 Jun 7.

DOI:10.1016/j.jmii.2013.03.013

PMID:23751770

Abstract

INTRODUCTION

The association between -336 A/G polymorphism of CD209 and susceptibility to/protection from tuberculosis is inconsistent.

AIM

The present study aimed at evaluating the possible association between CD209 rs4804803 (-336 A/G) gene polymorphism and pulmonary tuberculosis (PTB) in a sample of Iranian population.

MATERIALS AND METHODS

This case-control study was performed on 156 PTB patients and 154 healthy individuals. Tetra-amplification refractory mutation system-polymerase chain reaction was used to detect the polymorphisms.

RESULTS

Our findings revealed that the CD209 rs4804803 increased the risk of PTB in codominant [odds ratio (OR) = 5.16, 95% confidence interval (CI) = 1.60-16.59, p = 0.006, GG vs. AA], dominant (OR = 1.69, 95% CI = 1.07-2.66, p = 0.024, AG + GG vs. AA), and recessive (OR = 4.20, 95% CI = 1.34-13.16, p = 0.014, GG vs. AA + AG) tested inheritance models. Furthermore, the rs4804803 G allele increased the risk of PTB (OR = 1.58, 95% CI = 1.12-2.23, p = 0.011) as compared to the A allele.

CONCLUSION

Our data suggest that CD209 rs4804803 polymorphism increased the risk of PTB in a sample of Iranian population.

摘要

简介

CD209-336A/G 多态性与结核病易感性/保护之间的关联不一致。

目的

本研究旨在评估伊朗人群中 CD209 rs4804803（-336A/G）基因多态性与肺结核（PTB）之间的可能关联。

材料和方法

这项病例对照研究共纳入 156 例 PTB 患者和 154 例健康对照者。采用四扩增难治性突变系统-聚合酶链反应检测多态性。

结果

我们的研究结果表明，CD209 rs4804803 在共显性模型[比值比（OR）=5.16，95%置信区间（CI）=1.60-16.59，p=0.006，GG 与 AA]、显性模型（OR=1.69，95%CI=1.07-2.66，p=0.024，AG+GG 与 AA）和隐性模型（OR=4.20，95%CI=1.34-13.16，p=0.014，GG 与 AA+AG）中增加了 PTB 的发病风险。此外，与 A 等位基因相比，rs4804803 的 G 等位基因增加了 PTB 的发病风险（OR=1.58，95%CI=1.12-2.23，p=0.011）。