Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Pol J Microbiol. 2013;62(1):3-16.
Low copy number plasmids cannot rely on the random segregation during bacterial cell division. To be stably maintained in the population they evolved two types of mechanisms (i) partition systems (PAR) that actively separate replicated plasmid molecules to the daughter cells and (ii) toxin-andidote systems (TA) that act after cell division to kill plasmid-less cells. Our knowledge of partition systems has been based mainly on analysis of plasmids from Gram-negative bacteria. Now, numerous partition systems of plasmids from Gram-positive bacteria have also been characterized and make significant contribution to our understanding of these mechanisms.
低拷贝数质粒不能依赖于细菌细胞分裂过程中的随机分配。为了在群体中稳定存在，它们进化出了两种机制：（i）分区系统（PAR），它将复制的质粒分子主动分离到子细胞中；（ii）毒素-解毒系统（TA），它在细胞分裂后杀死无质粒的细胞。我们对分区系统的了解主要基于对革兰氏阴性菌质粒的分析。现在，革兰氏阳性菌质粒的许多分区系统也已经被描述，这对我们理解这些机制有重要贡献。
