细胞外甘油醛-3-磷酸脱氢酶在化脓性链球菌毒力中的作用。
Role of extracellular GAPDH in Streptococcus pyogenes virulence.
作者信息
Seidler Kirsten A, Seidler Norbert W
机构信息
University of Missouri, USA.
出版信息
Mo Med. 2013 May-Jun;110(3):236-40.
Abstract
Pathogens generate molecules, or virulence factors, that enable them to colonize host tissues through several mechanisms, including adhesion to host tissues, or superior invasive capability. Some allow the pathogen to evade the host's immune system. Many of these molecules are proteins that are exported to the cell's surface or secreted. Curiously, GAPDH, which is a glycolytic enzyme, is also a virulence factor that has been shown to contribute to Streptococcus pyogenes pathogenicity by each of these mechanisms.
摘要
病原体产生分子或毒力因子，使其能够通过多种机制在宿主组织中定殖，包括粘附于宿主组织或具有更强的侵袭能力。有些毒力因子能使病原体逃避宿主的免疫系统。其中许多分子是输出到细胞表面或分泌的蛋白质。奇怪的是，甘油醛-3-磷酸脱氢酶（GAPDH）作为一种糖酵解酶，也是一种毒力因子，已被证明可通过上述每种机制促进化脓性链球菌的致病性。
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