化脓性链球菌蛋白质组：图谱、毒力因子和疫苗候选物。
The Streptococcus pyogenes proteome: maps, virulence factors and vaccine candidates.
机构信息
Department of Molecular Microbiology, Institute of Experimental Medicine. acad. Pavlov str., 12, Saint-Petersburg, 197376, Russia.
出版信息
Future Microbiol. 2010 Oct;5(10):1539-51. doi: 10.2217/fmb.10.116.
Abstract
Streptococcus pyogenes is an important cause of human morbidity and mortality worldwide. A wealth of genomic information related to this pathogen has facilitated exploration of the proteome, particularly in response to environmental conditions thought to mimic various aspects of pathogenesis. Proteomic approaches are also used to identify immunoreactive proteins for vaccine development and to identify proteins that may induce autoimmunity. These studies have revealed new mechanisms involved in regulating the S. pyogenes proteome, which has opened up new avenues in the study of S. pyogenes pathogenesis. This article describes the methods used, and progress being made towards characterizing the S. pyogenes proteome, including studies seeking to identify potential vaccine candidates.
摘要
化脓链球菌是全球范围内导致人类发病率和死亡率的重要原因。大量与该病原体相关的基因组信息促进了对蛋白质组的探索，特别是针对那些被认为模拟发病机制各个方面的环境条件。蛋白质组学方法还用于鉴定用于疫苗开发的免疫反应性蛋白，并鉴定可能诱导自身免疫的蛋白质。这些研究揭示了调节化脓链球菌蛋白质组的新机制，为化脓链球菌发病机制的研究开辟了新途径。本文描述了所使用的方法以及在描述化脓链球菌蛋白质组方面取得的进展，包括试图确定潜在疫苗候选物的研究。
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