经至少 1 年局部睾酮和芳香化酶抑制剂治疗的克氏综合征青少年成功进行睾丸精子提取。
Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor.
机构信息
Department of Urology, Weill Cornell Medical College, New York, New York.
出版信息
Fertil Steril. 2013 Oct;100(4):970-4. doi: 10.1016/j.fertnstert.2013.06.010. Epub 2013 Jul 2.
OBJECTIVE
To evaluate surgical sperm retrieval rates in adolescents with Klinefelter syndrome and testosterone replacement therapy (TRT).
DESIGN
Case series.
SETTING
Academic medical center.
PATIENT(S): Ten patients with Klinefelter syndrome, aged 14-22 years, treated with testosterone replacement and aromatase inhibitor therapy for a period of 1-5 years before surgical sperm retrieval.
INTERVENTION(S): Microsurgical testis sperm extraction with cryopreservation of harvested tissue.
MAIN OUTCOME MEASURE(S): Presence of spermatozoa within testis tissue.
RESULT(S): Successful sperm retrieval in 7/10 patients (70%).
CONCLUSION(S): Use of topical TRT did not appear to suppress spermatogenesis in adolescents with KS. It is uncertain whether sperm retrieval rates would be higher or lower without testosterone replacement in these young males. Sperm cryopreservation should be discussed in all KS adolescents who are either receiving or considering initiating TRT.
目的
评估克氏综合征（Klinefelter syndrome）青少年在接受睾酮替代治疗（testosterone replacement therapy，TRT）时行外科取精术的精子获取率。
设计
病例系列研究。
地点
学术医疗中心。
患者
10 名患者患有克氏综合征，年龄 14-22 岁，在接受外科取精术之前已接受了 1-5 年的睾酮替代和芳香化酶抑制剂治疗。
干预措施
显微睾丸精子提取术，采集的组织进行冷冻保存。
主要观察指标
睾丸组织中是否存在精子。
结果
7/10 名患者（70%）成功获取精子。
结论
局部使用 TRT 似乎并未抑制克氏综合征青少年的生精功能。如果这些年轻男性不接受睾酮替代治疗，精子获取率是否会更高或更低尚不确定。对于正在接受或考虑开始 TRT 的所有克氏综合征青少年，应讨论精子冷冻保存问题。
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