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微小RNA在爱泼斯坦-巴尔病毒相关的移植后平滑肌瘤中的表达与平滑肌瘤表型相关。

MicroRNA expression in Epstein-Barr virus-associated post-transplant smooth muscle tumours is related to leiomyomatous phenotype.

作者信息

Jonigk Danny, Izykowski Nicole, Maegel Lavinia, Schormann Eileen, Maecker-Kolhoff Britta, Laenger Florian, Kreipe Hans, Hussein Kais

机构信息

Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str, 1, Hannover, D-30625, Germany.

出版信息

Clin Sarcoma Res. 2013 Jul 6;3(1):9. doi: 10.1186/2045-3329-3-9.

DOI:10.1186/2045-3329-3-9
PMID:23830214
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3706214/
Abstract

Epstein-Barr virus (EBV)-associated post-transplant smooth muscle tumours (PTSMT) are rare complications. In our previous molecular analysis, we have evaluated the expression of regulatory microRNA which are known to be EBV-related (miR-146a and miR-155) but found no deregulation in PTSMT. In this current analysis, we aimed to characterize the expression profiles of several hundred microRNA. Tissue samples from PTSMT and uterine leiomyomas were analysed by quantitative real-time PCR for the expression of 365 mature microRNA. PTSMT and leiomyomas share a highly similar microRNA profile, e.g. strong expression of miR-143/miR-145 cluster and low expression of miR-200c. Among EBV-related microRNA (miR-10b, miR-21, miR-29b, miR-34a, miR-127, miR-146a, miR-155, miR-200b, miR-203 and miR-429) only miR-10b and miR-203 were significantly deregulated. The expression pattern of microRNA in PTSMT is not associated with EBV infection but reflects the leiomyomatous differentiation of the tumour cells.

摘要

爱泼斯坦-巴尔病毒（EBV）相关的移植后平滑肌肿瘤（PTSMT）是罕见的并发症。在我们之前的分子分析中，我们评估了已知与EBV相关的调控性微小RNA（miR-146a和miR-155）的表达，但在PTSMT中未发现失调。在本次分析中，我们旨在表征数百种微小RNA的表达谱。通过定量实时PCR分析PTSMT和子宫平滑肌瘤的组织样本中365种成熟微小RNA的表达。PTSMT和平滑肌瘤具有高度相似的微小RNA谱，例如miR-143/miR-145簇的强表达和miR-200c的低表达。在与EBV相关的微小RNA（miR-10b、miR-21、miR-29b、miR-34a、miR-127、miR-146a、miR-155、miR-200b、miR-203和miR-429）中，只有miR-10b和miR-203有明显失调。PTSMT中微小RNA的表达模式与EBV感染无关，而是反映了肿瘤细胞的平滑肌瘤样分化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d843/3706214/e2adadb77062/2045-3329-3-9-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d843/3706214/e2adadb77062/2045-3329-3-9-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d843/3706214/e2adadb77062/2045-3329-3-9-1.jpg

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