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探索中风的遗传基础。西班牙中风遗传学联盟。

Exploring the genetic basis of stroke. Spanish stroke genetics consortium.

作者信息

Giralt-Steinhauer E, Jiménez-Conde J, Soriano Tárraga C, Mola M, Rodríguez-Campello A, Cuadrado-Godia E, Ois A, Fernández-Cádenas I, Carrera C, Montaner J, Díaz Navarro R M, Vives-Bauzá C, Roquer J

机构信息

Grupo de Investigación Neurovascular, Departamento de Neurología, IMIM-Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, España.

Grupo de Investigación Neurovascular, Departamento de Neurología, IMIM-Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, España.

出版信息

Neurologia. 2014 Nov-Dec;29(9):560-6. doi: 10.1016/j.nrl.2013.04.005. Epub 2013 Jul 5.

Abstract

This article provides an overview of stroke genetics studies ranging from the candidate gene approach to more recent studies by the genome wide association. It highlights the complexity of stroke owing to its different aetiopathogenic mechanisms, the difficulties in studying its genetic component, and the solutions provided to date. The study emphasises the importance of cooperation between the different centres, whether this takes places occasionally or through the creation of lasting consortiums. This strategy is currently essential to the completion of high-quality scientific studies that allow researchers to gain a better knowledge of the genetic component of stroke as it relates to aetiology, treatment, and prevention.

摘要

本文概述了中风遗传学研究,范围从候选基因方法到最近的全基因组关联研究。它强调了中风因其不同的病因发病机制而具有的复杂性、研究其遗传成分的困难以及迄今为止所提供的解决方案。该研究强调了不同中心之间合作的重要性,无论这种合作是偶尔进行还是通过建立持久的联盟来实现。目前,这一策略对于完成高质量的科学研究至关重要,这些研究能让研究人员更好地了解中风与病因、治疗和预防相关的遗传成分。

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