[药代动力学生理模型中计算组织/血液分配系数的一种新方法]
[A new method of calculating tissue/blood distribution coefficient in physiological models of pharmacokinetics].
作者信息
Manuĭlov K K, Kashina L B
出版信息
Antibiot Khimioter. 1990 May;35(5):35-6.
PMID:2383153
Abstract
An original simple method for evaluating the tissue/blood distribution coefficient for physiological models of drug pharmacokinetics on the basis of minimal information on the content of a xenobiotic in tissues (one time point) is described. For its testing, the literature data on the pharmacokinetics of sulbactam, ampicillin, THR-221 and NY-198 were used.
摘要
描述了一种基于关于组织中外源生物含量的最少信息（一个时间点）来评估药物药代动力学生理模型的组织/血液分配系数的原始简单方法。为了对其进行测试，使用了有关舒巴坦、氨苄西林、THR-221和NY-198药代动力学的文献数据。
Zotero 插件